Egr2 activates Hoxa2 chromatin

Stable Identifier
Reaction [BlackBoxEvent]
Mus musculus

Hoxa2 expression in embryos is driven by Egr2 (Krox20) in rhombomeres 3 and 5 (r3, r5) (Maconochie et al. 2001) and by Hoxb1 in r4 (Tumpel et al. 2007, Lampe et al. 2008). Egr2 binds sites in the 5' region of the Hoxa2 gene (Maconochie et al.2001). (Hoxa2 is the only Hox gene active in r2 (Lampe et al 2004). An unknown activator, possibly a transcription factor of the Sox family, may be involved in expression in r2 (Tumpel et al. 2008)).

Literature References
PubMed ID Title Journal Year
15033486 The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element

Lampe, X, Picard, JJ, Rezsohazy, R

Biochem. Biophys. Res. Commun. 2004
17113575 Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1

Tümpel, S, Cambronero, F, Ferretti, E, Blasi, F, Wiedemann, LM, Krumlauf, R

Dev. Biol. 2007
19104046 A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2

Tümpel, S, Cambronero, F, Sims, C, Krumlauf, R, Wiedemann, LM

Proc. Natl. Acad. Sci. U.S.A. 2008
18417536 An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4

Lampe, X, Samad, OA, Guiguen, A, Matis, C, Remacle, S, Picard, JJ, Rijli, FM, Rezsohazy, R

Nucleic Acids Res. 2008
11336508 Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development

Maconochie, MK, Nonchev, S, Manzanares, M, Marshall, H, Krumlauf, R

Dev. Biol. 2001
Orthologous Events