Egr2 (Krox20) activates Hoxb2 expression

Stable Identifier
R-MMU-5619430
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Egr2 (Krox20) activates Hoxb2 expression

Egr2 (Krox20) binds three sites in the 5' region of the Hoxb2 gene and activates expression in rhombomere 3 (r3) and r5 (Sham et al. 1993, Maconochie et al. 2001, Ferrai et al. 2009). Hoxb1 activates Hoxb2 in r4 and expression is also observed in r6 and r7.

Literature References
PubMed ID Title Journal Year
11336508 Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development

Maconochie, MK, Nonchev, S, Manzanares, M, Marshall, H, Krumlauf, R

Dev. Biol. 2001
8093858 The zinc finger gene Krox20 regulates HoxB2 (Hox2.8) during hindbrain segmentation

Sham, MH, Vesque, C, Nonchev, S, Marshall, H, Frain, M, Gupta, RD, Whiting, J, Wilkinson, D, Charnay, P, Krumlauf, R

Cell 1993
Participants
Orthologous Events
Authored
Reviewed
Created