Reactome | Retinoic acid activates Hoxa4 chromatin

Retinoic acid activates Hoxa4 chromatin

Stable Identifier

R-MMU-5619434

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm

ReviewStatus

5/5

General

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In mouse embryos retinoic acid initially activates expression of the Hoxa4 gene in rhombomere 7 (r7) and regions of mesoderm by binding Rarb or Rara in dimeric Rar:Rxr complexes located at retinoic acid response elements (RAREs) in the 5' flanking region of the Hoxa4 promoter (Behringer et al. 1993, Morrison et al. 1997, Packer et al. 1998, Packer et al. 2000), causing dissociation of corepressors and recruitment of corepressors (inferred from Hoxa1, Gillespie and Gudas 2007, Kashyap and Gudas 2010). Hoxa4 itself maintains later expression in an autoregulatory loop (Wu and Wolgemuth 1993, Packer et al. 1998).
Treatment of embryonic stem cells with retinoic acid causes loss of methylation at histone 3 lysine-27 (H3K27me3, Kashyap et al. 2011, Mazzoni et al. 2013, Shpargel et al. 2014), loss of Polycomb repressive complex 2 (PRC2, Mazzoni et al. 2013) and gain of methylation at histone 3 lysine-4 (H3K4me3, Kashyap et al. 2011) across the Hoxa gene cluster. The Mll2 complex methylates H3K4 at Hoxa4 in fibroblasts (Wang et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
9272954	HOXD4 and regulation of the group 4 paralog genes Morrison, A, Ariza-McNaughton, L, Gould, A, Featherstone, M, Krumlauf, R	Development	1997
17663992	Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells Gillespie, RF, Gudas, LJ	J. Mol. Biol.	2007
20231276	Epigenetic regulatory mechanisms distinguish retinoic acid-mediated transcriptional responses in stem cells and fibroblasts Kashyap, V, Gudas, LJ	J. Biol. Chem.	2010
19703992	Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II Wang, P, Lin, C, Smith, ER, Guo, H, Sanderson, BW, Wu, M, Gogol, M, Alexander, T, Seidel, C, Wiedemann, LM, Ge, K, Krumlauf, R, Shilatifard, A	Mol. Cell. Biol.	2009
21087926	Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid Kashyap, V, Gudas, LJ, Brenet, F, Funk, P, Viale, A, Scandura, JM	J. Biol. Chem.	2011
10679930	Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning Packer, AI, Mailutha, KG, Ambrozewicz, LA, Wolgemuth, DJ	Dev. Dyn.	2000
25101834	KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development Shpargel, KB, Starmer, J, Yee, D, Pohlers, M, Magnuson, T	PLoS Genet.	2014
9570764	Expression of the murine Hoxa4 gene requires both autoregulation and a conserved retinoic acid response element Packer, AI, Crotty, DA, Elwell, VA, Wolgemuth, DJ	Development	1998
23955559	Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals Mazzoni, EO, Mahony, S, Peljto, M, Patel, T, Thornton, SR, McCuine, S, Reeder, C, Boyer, LA, Young, RA, Gifford, DK, Wichterle, H	Nat. Neurosci.	2013
8100763	Sequences 5' of the homeobox of the Hox-1.4 gene direct tissue-specific expression of lacZ during mouse development Behringer, RR, Crotty, DA, Tennyson, VM, Brinster, RL, Palmiter, RD, Wolgemuth, DJ	Development	1993
7901228	Protein product of the somatic-type transcript of the Hoxa-4 (Hox-1.4) gene binds to homeobox consensus binding sites in its promoter and intron Wu, K, Wolgemuth, DJ	J. Cell. Biochem.	1993

Participants

Input

Output

Orthologous Events

Retinoic acid activates HOXA4 chromatin (Homo sapiens)

Authored

May, B (2014-08-16)

Rezsohazy, R (2015-11-15)

Reviewed

Blasi, F (2015-05-13)

Created

May, B (2014-08-22)