Hoxc4 chromatin is activated

Stable Identifier
Reaction [BlackBoxEvent]
Mus musculus

Hoxc4 is expressed in embryos at E12.5 caudal to rhombomere 7 (r7, Geada et al. 1992). Hoxc4 is also expressed at the level of prevertebrae 4-5, in spinal column, esophagus, lung, trachea, and metanephric kidney (Geada et al. 1992). Vitamin A (and hence retinoic acid) appears to induce expression of Hoxc4 (Liu and Zhu 2000). Hoxc4 is induced by beta-catenin during neurogenesis of embryonic stem cells (Otero et al. 2004). Chromatin at Hoxc4 loses methylation at lysine-27 of histone H3 (H3K27me3), loses polycomb repressive complex 2 (PRC2), and gains methylation at lysine-4 of histone H3 (H3K4me3) during treatment of embryonic stem cells with retinoic acid (Mazzoni et al. 2013).

Literature References
PubMed ID Title Journal Year
12725064 [Effects of vitamin A on Hox 3.5 gene expression in mouse embryo]

Liu, G, Zhu, Q

Wei Sheng Yan Jiu 2000
15262888 Beta-catenin signaling is required for neural differentiation of embryonic stem cells

Otero, JJ, Fu, W, Kan, L, Cuadra, AE, Kessler, JA

Development 2004
1363091 Sequence and embryonic expression of the murine Hox-3.5 gene

Geada, AM, Gaunt, SJ, Azzawi, M, Shimeld, SM, Pearce, J, Sharpe, PT

Development 1992
23955559 Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

Mazzoni, EO, Mahony, S, Peljto, M, Patel, T, Thornton, SR, McCuine, S, Reeder, C, Boyer, LA, Young, RA, Gifford, DK, Wichterle, H

Nat. Neurosci. 2013
Orthologous Events