Reactome | Asap1 [cytosol]

Asap1 [cytosol]

Stable Identifier

R-MMU-5620905

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ASAP1, Q9QWY8

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Mus musculus)

- Cilium Assembly (Mus musculus)
  - Cargo trafficking to the periciliary membrane (Mus musculus)
    - VxPx cargo-targeting to cilium (Mus musculus)
      - ASAP1 recruits RAB11FIP3 and RAB11 to the ciliary targeting complex (Mus musculus)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
      - ASAP1 stimulates GTPase activity of ARF4 (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer: ARF4:GTP:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
      - Cargo-carrying vesicles bud from the TGN (Mus musculus)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
      - RAB3IP and RAB8A bind to the ciliary targeting complex (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
      - RAB3IP stimulates nucleotide exchange on RAB8A (Mus musculus)
        
        RAB8A:GDP:RAB3IP:RAB11A:GTP:FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
      - The exocyst complex binds to RAB3IP in the ciliary targeting complex (Mus musculus)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
        
        exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)
      - VxPx-containing ciliary membrane proteins are delivered to the ciliary membrane (Mus musculus)
        
        exocyst complex:RAB8A:GTP:RAB3IP:RAB11:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        RAB8A:GTP:RAB3IP:RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        RAB11A:GTP:RAB11FIP3 dimer:ASAP1 dimer:VxPx-containing ciliary membrane proteins [Golgi-associated vesicle membrane] (Mus musculus)
        
        ASAP1 dimer [cytosol] (Mus musculus)
        
        Asap1 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9QWY8 Asap1

Gene Names

Asap1, Ddef1, Kiaa1249, Shag1

Chain

chain:1-1147

Reference Genes

BioGPS Gene:13196 ASAP1

KEGG:mmu:13196 ASAP1

Monarch:13196 ASAP1

NCBI Gene:13196 ASAP1

UCSC:Q9QWY8 ASAP1

Reference Transcript

Participates

as a component of

ASAP1 dimer [cytosol] (Mus musculus)

Other forms of this molecule

Asap1 [cytosol]

Inferred From

ASAP1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001263396.1, XP_036015010.1, NP_001398114.1, NP_001263391.1, NP_001263390.1, NP_034156.2

ENSEMBL

ENSMUSP00000135190, ENSMUSG00000022377, ENSMUSP00000135718, ENSMUSP00000134825, ENSMUST00000110115, ENSMUST00000177374, ENSMUSP00000105742, ENSMUST00000175793, ENSMUST00000176384

PRO

Q9QWY8

GlyGen

Q9QWY8

MGI

1342335

PDB

5C79, 8ZE8, 5C6R, 8HLO

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9QVP9	3	phospho-Ptk2b [cytosol] (R-MMU-508515) Ptk2b [cytosol] (R-MMU-390932) phospho-Ptk2b [cytosol] (R-MMU-5218721)	0.645	5
UniProt:P84080	2	ARF1 [cytosol] (R-BTA-200826) ARF1 [Golgi membrane] (R-BTA-199971)	0.558	2

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