Hoxb1 activates Hoxb2 expression

Stable Identifier
R-MMU-5621004
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Summation

Hoxb1 in a trimeric complex with Pbx1 and Meis1 or Pknox1 (Prep1) binds an enhancer located 5' to the Hoxb2 gene and activates expression of Hoxb2 in rhombomere 4 (r4) of embryos (Maconochie et al. 1997, Jacobs et al. 1999, Ferretti et al. 2000, Ferrai et al. 2009). Egr2 (Krox20) activates Hoxb2 in r3 and r5 and expression is also observed in r6 and r7.

Literature References
PubMed ID Title Journal Year
9242495 Cross-regulation in the mouse HoxB complex: the expression of Hoxb2 in rhombomere 4 is regulated by Hoxb1

Maconochie, MK, Nonchev, S, Studer, M, Chan, SK, Pöpperl, H, Sham, MH, Mann, RS, Krumlauf, R

Genes Dev. 1997
19477923 Induction of HoxB transcription by retinoic acid requires actin polymerization

Ferrai, C, Naum-Onganía, G, Longobardi, E, Palazzolo, M, Disanza, A, Diaz, VM, Crippa, MP, Scita, G, Blasi, F

Mol. Biol. Cell 2009
10654609 Segmental expression of Hoxb2 in r4 requires two separate sites that integrate cooperative interactions between Prep1, Pbx and Hox proteins

Ferretti, E, Marshall, H, Pöpperl, H, Maconochie, M, Krumlauf, R, Blasi, F

Development 2000
10373562 Trimeric association of Hox and TALE homeodomain proteins mediates Hoxb2 hindbrain enhancer activity

Jacobs, Y, Schnabel, CA, Cleary, ML

Mol. Cell. Biol. 1999
Participants
Orthologous Events
Authored
Reviewed