Hoxb1 activates Hoxa2 expression

Stable Identifier
R-MMU-5621012
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Summation

Hoxa2 expression is driven by Hoxb1 in rhombomere 4 (r4) (Tumpel et al. 2007, Lampe et al. 2008) and Egr2 (Krox20) in r3 and r5 (Maconochie et al. 2001). Hoxb1 together with Pbx and Prep/Meis cofactors bind an element in the intron of Hoxa2 (Tumpel et al. 2007, Lampe et al. 2008, Tumpel et al. 2008). Hoxa2 also autoregulates in r4 (Tumpel et al. 2007, Lampe et al. 2008). (Hoxa2 is the only Hox gene active in r2 (Lampe et al 2004). An unknown activator, possibly a transcription factor of the Sox family, may be involved in expression in r2 (Tumpel et al. 2008)).

Literature References
PubMed ID Title Journal Year
15033486 The Hoxa2 enhancer 2 contains a critical Hoxa2 responsive regulatory element

Lampe, X, Picard, JJ, Rezsohazy, R

Biochem. Biophys. Res. Commun. 2004
17113575 Expression of Hoxa2 in rhombomere 4 is regulated by a conserved cross-regulatory mechanism dependent upon Hoxb1

Tümpel, S, Cambronero, F, Ferretti, E, Blasi, F, Wiedemann, LM, Krumlauf, R

Dev. Biol. 2007
19104046 A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2

Tümpel, S, Cambronero, F, Sims, C, Krumlauf, R, Wiedemann, LM

Proc. Natl. Acad. Sci. U.S.A. 2008
18417536 An ultraconserved Hox-Pbx responsive element resides in the coding sequence of Hoxa2 and is active in rhombomere 4

Lampe, X, Samad, OA, Guiguen, A, Matis, C, Remacle, S, Picard, JJ, Rijli, FM, Rezsohazy, R

Nucleic Acids Res. 2008
11336508 Differences in Krox20-dependent regulation of Hoxa2 and Hoxb2 during hindbrain development

Maconochie, MK, Nonchev, S, Manzanares, M, Marshall, H, Krumlauf, R

Dev. Biol. 2001
Participants
Orthologous Events
Authored
Reviewed