Plcg1 binds p-Y348,352,525,526-Syk

Stable Identifier
R-MMU-5621346
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Plcg1 binds p-Y348,352,525,526-Syk
Phospholipase C-gamma (PLCG) binds to phosphorylated Tyr-348 (Tyr-342 in mouse) and Tyr-352 (Tyr-346 in mouse) in SYK with its C-terminal SH2 domain (Law et al. 1996). PLCG2 functions downstream of CLEC6A/Dectin-2 and triggers cytokine production in response to the infection by Candida albicans. PLCG2 deficiency results in the defective production of NF-kB and significantly reduced production of reactive oxygen species (ROS) following infection (Gorjestani et al. 2011).
Literature References
PubMed ID Title Journal Year
22041900 Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses

Zhang, D, Tang, B, Yu, M, Wang, D, Gorjestani, S, Lin, X

J. Biol. Chem. 2011
8657103 Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

Chandran, KA, Law, CL, Clark, EA, Sidorenko, SP

Mol Cell Biol 1996
Participants
Input
Output
Orthologous Events
PLCG1 binds p-6Y-SYK:p-Y65,Y76-FCER1G (Homo sapiens)
Authored
Garapati, P V  (2014-08-29)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-08-29)
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