Plcg1 binds p-Y348,352,525,526-Syk

Stable Identifier
R-MMU-5621346
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Plcg1 binds p-Y348,352,525,526-Syk

Phospholipase C-gamma (PLCG) binds to phosphorylated Tyr-348 (Tyr-342 in mouse) and Tyr-352 (Tyr-346 in mouse) in SYK with its C-terminal SH2 domain (Law et al. 1996). PLCG2 functions downstream of CLEC6A/Dectin-2 and triggers cytokine production in response to the infection by Candida albicans. PLCG2 deficiency results in the defective production of NF-kB and significantly reduced production of reactive oxygen species (ROS) following infection (Gorjestani et al. 2011).

Literature References
PubMed ID Title Journal Year
8657103 Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk

Law, CL, Chandran, KA, Sidorenko, SP, Clark, EA

Mol Cell Biol 1996
22041900 Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses

Gorjestani, S, Yu, M, Tang, B, Zhang, D, Wang, D, Lin, X

J. Biol. Chem. 2011
Participants
Orthologous Events
Authored
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