Cit binds activated Rhoa, Rhob, Rhoc and Rac1

Stable Identifier
R-MMU-5625893
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cit binds activated Rhoa, Rhob, Rhoc and Rac1
Using mouse Rhoa, Rhob, Rhoc and Rac1 constructs and a mouse cDNA library to perform a yeast two hybrid screen, Cit (citron kinase) was identified as a protein with a strong binding affinity for GTP-bound Rhoa, Rhob, Rhoc and Rac1. Based on its sequence, Cit is likely to function as a dimer (Madaule et al. 1995).
Literature References
PubMed ID Title Journal Year
8543060 A novel partner for the GTP-bound forms of rho and rac

Madaule, P, Narumiya, S, Furuyashiki, T, Watanabe, G, Reid, T, Ishizaki, T, Morii, N

FEBS Lett. 1995
Participants
Input
Output
Orthologous Events
CIT (citron kinase) binds activated RHOA, RHOB, RHOC and RAC1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2014-10-08)
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