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Smo dimer binds Arrb and Kif3a

Stable Identifier
R-MMU-5632657
Type
Reaction
Species
Mus musculus
Compartment
Summation

Beta arrestin 1 and 2 (Arrb1 and 2) and Kif3a are required for the ciliary concentration of Smo after ligand stimulation, and the three proteins co-immunoprecipitate after treatment of NIH3T3 cells with Shh. Arrb proteins mediate the interaction between Smo and Kif3a, and the kinesin motor protein appears to promote the transport of Smo to the primary cilium (Kovacs et al, 2008).

Literature References
PubMed ID Title Journal Year
18497258 Beta-arrestin-mediated localization of smoothened to the primary cilium Science 2008
Participants
Orthologous Events