Csnk1a1 binds Smo dimer

Stable Identifier
R-MMU-5632658
Type
Reaction
Species
Mus musculus
Compartment
Summation

Csnk1a1 binds the Smo C-terminal tail after Shh stimulation as an early step in Smo activation. Csnk1a1-mediated phosphorylation of serine residues in the S0 and S1 motifs enhances binding of both Csnk1a1 and Adrbk1/Grk2 to the C-terminal tail of Smo, increasing its phosphorylation of the and promoting an open, active conformation of the tail (Chen et al, 2010; Chen et al, 2011).

Literature References
PubMed ID Title Journal Year
20844016 G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

Chen, Y, Li, S, Tong, C, Zhao, Y, Wang, B, Liu, Y, Jia, J, Jiang, J

Genes Dev. 2010
21695114 Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened

Chen, Y, Sasai, N, Ma, G, Yue, T, Jia, J, Briscoe, J, Jiang, J

PLoS Biol. 2011
Participants
Orthologous Events
Authored
Reviewed