Reactome: A Curated Pathway Database

Csnk1a1 phosphorylates Smo dimer

Stable Identifier
R-MMU-5632661
Type
Reaction
Species
Mus musculus
Compartment
Summation

Numerous residues in the C-terminal tail of Smo are phosphorylated by Csnk1a1 as assessed by an in vitro kinase assay. Of these, residues S592, S594, T597 and S599 in the S0 region appear to play the most important role in Smo activation in response to Shh. Initial phosphorylation by Csnk1a promotes further phosphorylation by both Csnk1a1 and by Ardbk1/Grk2, and phosphorylation is required to promote a conformational change in the C-terminal Smo tail that is required to propagate the Hh signal to downstream effectors (Chen et al, 2011; Chen et al, 2010; Zhao et al, 2007).

Literature References
Participants
This entity is regulated by:
Title Physical Entity Activity
protein serine/threonine kinase activity of Smo dimer:Csnk1a1 [ciliary membrane] Smo dimer:Csnk1a1 [ciliary membrane] protein serine/threonine kinase activity (0004674)
Orthologous Events