Csnk1a1 phosphorylates Smo dimer

Stable Identifier
R-MMU-5632661
Type
Reaction
Species
Mus musculus
Compartment
Summation

Numerous residues in the C-terminal tail of Smo are phosphorylated by Csnk1a1 as assessed by an in vitro kinase assay. Of these, residues S592, S594, T597 and S599 in the S0 region appear to play the most important role in Smo activation in response to Shh. Initial phosphorylation by Csnk1a promotes further phosphorylation by both Csnk1a1 and by Ardbk1/Grk2, and phosphorylation is required to promote a conformational change in the C-terminal Smo tail that is required to propagate the Hh signal to downstream effectors (Chen et al, 2011; Chen et al, 2010; Zhao et al, 2007).

Literature References
PubMed ID Title Journal Year
20844016 G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

Chen, Y, Li, S, Tong, C, Zhao, Y, Wang, B, Liu, Y, Jia, J, Jiang, J

Genes Dev. 2010
21695114 Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened

Chen, Y, Sasai, N, Ma, G, Yue, T, Jia, J, Briscoe, J, Jiang, J

PLoS Biol. 2011
17960137 Hedgehog regulates smoothened activity by inducing a conformational switch

Zhao, Y, Tong, C, Jiang, J

Nature 2007
Participants
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of Smo dimer:Csnk1a1 [ciliary membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed