Adrbk1 phosphorylates Smo dimer

Stable Identifier
R-MMU-5632665
Type
Reaction
Species
Mus musculus
Compartment
Summation

Adrbk1 phosphorylates the Smo C-terminal tail in the S1 to S5 regions in vitro, however the S1 sites S615, 619 and 620 appear to be the most critical (Chen et al, 2011). Phosphorylation promotes a conformational change that is required for downstream signal propagation in mouse and Drosophila (Chen et al, 2011; Chen et al, 2010; Zhao et al, 2007).

Literature References
PubMed ID Title Journal Year
21695114 Sonic Hedgehog dependent phosphorylation by CK1? and GRK2 is required for ciliary accumulation and activation of smoothened

Chen, Y, Sasai, N, Ma, G, Yue, T, Jia, J, Briscoe, J, Jiang, J

PLoS Biol. 2011
22986504 Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

Yang, C, Chen, W, Chen, Y, Jiang, J

Cell Res. 2012
20844016 G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

Chen, Y, Li, S, Tong, C, Zhao, Y, Wang, B, Liu, Y, Jia, J, Jiang, J

Genes Dev. 2010
Participants
Orthologous Events
Authored
Reviewed