Reactome: A Curated Pathway Database

Adrbk1 phosphorylates Smo dimer

Stable Identifier
R-MMU-5632665
Type
Reaction
Species
Mus musculus
Compartment
Summation

Adrbk1 phosphorylates the Smo C-terminal tail in the S1 to S5 regions in vitro, however the S1 sites S615, 619 and 620 appear to be the most critical (Chen et al, 2011). Phosphorylation promotes a conformational change that is required for downstream signal propagation in mouse and Drosophila (Chen et al, 2011; Chen et al, 2010; Zhao et al, 2007).

Literature References
Participants
Orthologous Events