Reactome | Spopl [nucleoplasm]

Spopl [nucleoplasm]

Stable Identifier

R-MMU-5635036

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

SPOPL, Q2M2N2

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Signaling by Hedgehog (Mus musculus)
  - Hedgehog 'on' state (Mus musculus)
    - GLI2,3 are degraded by the proteasome (Mus musculus)
      - SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP dimer [nucleoplasm] (Mus musculus)
        
        SPOP:SPOPL [nucleoplasm] (Mus musculus)
        
        Spopl [nucleoplasm] (Mus musculus)
      - ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP dimer [nucleoplasm] (Mus musculus)
        
        SPOP:SPOPL [nucleoplasm] (Mus musculus)
        
        Spopl [nucleoplasm] (Mus musculus)
    - SPOP:CUL3:RBX1 ubiquitinates GLI2,3 (Mus musculus)
      - 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP dimer [nucleoplasm] (Mus musculus)
        
        SPOP:SPOPL [nucleoplasm] (Mus musculus)
        
        Spopl [nucleoplasm] (Mus musculus)
      - ub-2p-GLI2,3:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP dimer [nucleoplasm] (Mus musculus)
        
        SPOP:SPOPL [nucleoplasm] (Mus musculus)
        
        Spopl [nucleoplasm] (Mus musculus)
    - phosphorylated GLI proteins bind SPOP:CUL3:RBX1 (Mus musculus)
      - 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP dimer [nucleoplasm] (Mus musculus)
        
        SPOP:SPOPL [nucleoplasm] (Mus musculus)
        
        Spopl [nucleoplasm] (Mus musculus)
      - SPOP:CUL3:RBX1 [nucleoplasm] (Mus musculus)
        
        SPOP dimer [nucleoplasm] (Mus musculus)
        
        SPOP:SPOPL [nucleoplasm] (Mus musculus)
        
        Spopl [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q2M2N2

Gene Names

Spopl

Reference Genes

BioGPS Gene:76857 Spopl

ENSEMBL:ENSMUSG00000026771

ENSEMBL:ENSMUSG00000026771.15 Spopl

KEGG Gene (Mus musculus):76857 Spopl

Monarch:76857 Spopl

NCBI Gene:76857 Spopl

UCSC:Q2M2N2 Spopl

Reference Transcript

Other Identifiers

10480445

1429121_at

1435274_at

165311_i_at

166659_i_at

17382186

4324128

4343973

4391425

4425177

4431705

4442783

4543213

4769950

4908181

4916352

4919392

4987590

5062700

5142674

5196324

5204446

5243302

5249439

5259144

5385675

5432384

5459416

76857

A_51_P395743

A_52_P408459

A_55_P2019914

A_66_P127243

GE105632

GO:0005515

GO:0005634

GO:0005737

GO:0016567

GO:0030162

GO:0030163

GO:0031397

GO:0031463

GO:0031625

GO:0036211

GO:0043161

GO:0043226

ILMN_2479118

ILMN_2729354

mMC013227

mMC025862

Participates

as a component of

SPOP:SPOPL [nucleoplasm] (Mus musculus)

Inferred From

SPOPL [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001159469.1, NP_084049.2, XP_006498477.1, NP_001159470.1, XP_017174813.1

Ensembl

ENSMUST00000132484, ENSMUSP00000114974, ENSMUSG00000026771

PRO

Q2M2N2

MGI

1924107

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