Reactome | Lamtor3 [lysosomal membrane]

Lamtor3 [lysosomal membrane]

Stable Identifier

R-MMU-5653581

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

lysosomal membrane

Synonyms

LAMTOR3, O88653

Locations in the PathwayBrowser

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Autophagy (Mus musculus)

- Macroautophagy (Mus musculus)
  - Active MTORC1 binds the ULK1 complex (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Active MTORC1 phosphorylates ULK1 (Mus musculus)
    - MTORC1:RHEB:GTP:ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - MTORC1 dissociates from ULK complex (Mus musculus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Rheb in the MTORC1 complex hydrolyses GTP (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Mus musculus)
    - MTORC1 with p-S722,S792-RPTOR:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - MTORC1:RHEB:GTP:p-S758-ULK1:ATG13:RB1CC1:ATG101 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to starvation (Mus musculus)
    - Amino acids regulate mTORC1 (Mus musculus)
      - RRAGA,B exchanges GDP for GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - RRAGA,B hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - RRAGC,D exchanges GTP for GDP (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - RRAGC,D hydrolyzes GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - mTORC1 binds RHEB:GTP (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Mus musculus)
        
        v-ATPase:Ragulator [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional Regulation by TP53 (Mus musculus)
      - TP53 Regulates Metabolic Genes (Mus musculus)
        
        RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - PIP3 activates AKT signaling (Mus musculus)
    - PTEN Regulation (Mus musculus)
      - Regulation of PTEN gene transcription (Mus musculus)
        
        MAF1 translocates to the nucleus (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
        
        mTORC1 phosphorylates MAF1 (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
- MTOR signalling (Mus musculus)
  - AKT1S1 (PRAS40) binds mTORC1 (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Activated Akt1 phosphorylates AKT1S1 (PRAS40) (Mus musculus)
    - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Energy dependent regulation of mTOR by LKB1-AMPK (Mus musculus)
    - AMPK phosphorylates Raptor in the mTORC1 complex (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - RHEB in mTORC1:RHEB:GTP hydrolyses GTP (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:Rag:GNP:RHEB:GDP [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Formation of Ragulator complex (Mus musculus)
    - Lamtor3 [lysosomal membrane] (Mus musculus)
    - Ragulator [lysosomal membrane] (Mus musculus)
      - Lamtor3 [lysosomal membrane] (Mus musculus)
  - Formation of active mTORC1 complex (Mus musculus)
    - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
      - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Phosphorylated AKT1S1:mTORC1 binds YWHAB (Mus musculus)
    - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Ragulator binds Rag dimers (Mus musculus)
    - Ragulator [lysosomal membrane] (Mus musculus)
      - Lamtor3 [lysosomal membrane] (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
      - Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - Ragulator:Rag dimers:SLC38A9 bind mTORC1 (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - SLC38A9 binds Ragulator:Rag dimers (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
      - Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - SLC38A9 transports L-Arg from lysosomal lumen to cytosol (Mus musculus)
    - Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
      - Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - mTORC1 phosphorylates AKT1S1 (Mus musculus)
    - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-S183,T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
  - mTORC1-mediated signalling (Mus musculus)
    - Phosphorylation of 4E-BP1 by activated mTORC1 (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - mTORC1:RHEB:GTP:AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
    - mTORC1 phosphorylation of RPS6KB1 (S6K) (Mus musculus)
      - Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - mTORC1 with p-S722,S792-RPTOR:Ragulator:Rag:GNP:RHEB:GTP [lysosomal membrane] (Mus musculus)
        
        mTORC1 with p-RPTOR:Ragulator:Rag:GNP [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)
      - mTORC1:p-T246-AKT1S1:YWHAB [lysosomal membrane] (Mus musculus)
        
        mTORC1:RHEB:GTP:p-T246-AKT1S1 [lysosomal membrane] (Mus musculus)
        
        Active mTORC1 complex [lysosomal membrane] (Mus musculus)
        
        mTORC1:Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP:SLC38A9 [lysosomal membrane] (Mus musculus)
        
        Ragulator:RagA,B:GTP:RagC,D:GDP [lysosomal membrane] (Mus musculus)
        
        Ragulator [lysosomal membrane] (Mus musculus)
        
        Lamtor3 [lysosomal membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:O88653

Gene Names

Lamtor3

Reference Genes

BioGPS Gene:56692 Lamtor3

ENSEMBL:ENSMUSG00000091512

KEGG:mmu:56692 Lamtor3

Monarch:56692 Lamtor3

NCBI Gene:56692 Lamtor3

UCSC:O88653 Lamtor3

Reference Transcript

RefSeq:NM_019920.2 Lamtor3

Other Identifiers

10496397

10566405

135884_at

1416272_at

160126_at

17403025

17494449

4337056

4363421

4394754

4395344

4432136

4546947

4565767

4578170

4716362

4749062

4765045

4813308

4819169

4942100

5230469

5256775

5334175

5399969

5467609

5518413

5559795

5569380

5612633

56692

A_51_P173555

A_52_P280085

A_55_P2060183

A_55_P2060184

GE1395209

GE37696

GO:0005085

GO:0005515

GO:0005765

GO:0005768

GO:0005770

GO:0008104

GO:0016020

GO:0019209

GO:0031410

GO:0031902

GO:0032006

GO:0032008

GO:0038202

GO:0043226

GO:0043410

GO:0060090

GO:0071230

GO:0071986

GO:0098772

GO:1902414

GO:1904263

GO:1990877

ILMN_1230008

aa616370_s_at

mMC025388

Participates

as an input of

Formation of Ragulator complex (Mus musculus)

as a component of

Ragulator [lysosomal membrane] (Mus musculus)

Other forms of this molecule

Lamtor3 [tertiary granule membrane]

Lamtor3 [plasma membrane]

Lamtor3 [specific granule membrane]

Lamtor3 [endosome membrane]

Inferred From

LAMTOR3 [lysosomal membrane] (Homo sapiens)

Cross References

RefSeq

NP_064304.1

ENSEMBL

ENSMUST00000197064, ENSMUST00000168345, ENSMUSP00000142512, ENSMUSP00000130811, ENSMUSG00000091512

PRO

O88653

MGI

1929467

PDB

1VEU, 1VET

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6P791	5	Lamtor1 [ficolin-1-rich granule membrane] (R-RNO-6801003) Lamtor1 [azurophil granule membrane] (R-RNO-6799633) Lamtor1 [plasma membrane] (R-RNO-6806270) Lamtor1 [specific granule membrane] (R-RNO-6799631) Lamtor1 [lysosomal membrane] (R-RNO-5653582)	0.644	5

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