p-Bmal1:p-Clock,Npas2 binds Per2 gene

Stable Identifier
R-MMU-5663114
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
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p-Bmal1:p-Clock,Npas2 binds Per2 gene
Bmal1:Clock (Arntl:Clock) and Bmal1:Npas2 (Arntl:Npas2) heterodimers bind E-box elements (consensus CACGTG) in the promoters of target genes. Two E-box elements separated by 6 bp are sufficient to confer circadian transcription on a reporter gene. The Per2 promoter has a noncanonical E-box and is regulated by Bmal1:Clock. Regulation by Bmal1:Npas2 has also been demonstrated, leading to the conclusion that Clock and Npas2 are at least partially redundant.
Literature References
PubMed ID Title Journal Year
15699353 A noncanonical E-box enhancer drives mouse Period2 circadian oscillations in vivo

Yoo, SH, Yamazaki, S, Buhr, ED, Song, EJ, Lee, C, Yoo, OJ, Lowrey, PL, Ko, CH, Takahashi, JS, Chang, S

Proc Natl Acad Sci U S A 2005
17417633 CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock

Reppert, SM, DeBruyne, JP, Weaver, DR

Nat Neurosci 2007
19330005 CK2alpha phosphorylates BMAL1 to regulate the mammalian clock

Hirayama, J, Nagai, K, Isojima, Y, Tamaru, T, Takamatsu, K, Sassone-Corsi, P, Norioka, S

Nat Struct Mol Biol 2009
12865428 Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes

Ishida, N, Horikoshi, M, Kobayashi, H, Kudo, T, Kadota, K, Umehara, T, Nagase, T, Horie, S, Monden, M, Matsuda, J, Miyazaki, K, Machida, K, Todo, T, Yano, M, Iitaka, C, Oishi, K, Yukimasa, S, Ohkura, N, Kikuno, R, Atsumi, G, Shimizu, Y, Mesaki, M, Azama, T

J Biol Chem 2003
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Orthologous Events
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