Rora, Ep300 bind Npas2 gene

Stable Identifier
R-MMU-5663256
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Rora, Ep300 bind Npas2 gene
Rora binds RRE DNA elements and recruits the coactivators PGC-1alpha (Ppargc1a) and p300 (Ep300, a histone acetylase). Rora binds the promoter of the Npas2 gene and enhances transcription.
Literature References
PubMed ID Title Journal Year
17476214 Transcriptional coactivator PGC-1alpha integrates the mammalian clock and energy metabolism

Liu, T, Lin, JD, Li, S, Borjigin, J, Liu, C

Nature 2007
20817722 Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene

Kojetin, DJ, Crumbley, C, Burris, TP, Wang, Y

J Biol Chem 2010
15199055 RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR

Parton, RG, Nixon, SJ, Lau, P, Muscat, GE

J Biol Chem 2004
Participants
Input
Output
Orthologous Events
RORA, EP300 bind NPAS2 gene (Homo sapiens)
Authored
May, B  (2015-01-16)
Reviewed
Delaunay, F  (2012-01-28)
Created
May, B  (2015-01-17)
Cite Us!