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Rora, Ep300 bind Srebf1 gene
Stable Identifier
R-MMU-5663291
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SBML
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Level 2
Level 3
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Rora binds the RRE DNA element and recruits the coactivators Pgc-1alpha (Ppargc1a) and p300 (Ep300, a histone acetyltransferase). Rora binds the promoter of the Srebf1 gene and enhances transcription.
Literature References
PubMed ID
Title
Journal
Year
18441015
The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity
Wang, SC
,
Lau, P
,
Fitzsimmons, RL
,
Raichur, S
,
Lechtken, A
,
Muscat, GE
J Biol Chem
2008
Participants
Input
Ep300 [nucleoplasm]
(Mus musculus)
Rora [nucleoplasm]
(Mus musculus)
Srebf1 gene [nucleoplasm]
(Mus musculus)
Output
Rora:Ep300:Srebf1 gene [nucleoplasm]
(Mus musculus)
Orthologous Events
RORA, EP300 bind SREBF1 gene (Homo sapiens)
Authored
May, B (2015-01-17)
Reviewed
Delaunay, F (2012-01-28)
Created
May, B (2015-01-17)
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