Ltbr binds lymphotoxin and Tnfsf14

Stable Identifier
R-MMU-5668798
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Ltbr binds lymphotoxin and Tnfsf14

Lymphotoxin-beta receptor (LTBR or TNFR3) is a tumor necrosis factor receptor superfamily (TNFRSF) member that is expressed in lymphoid stromal and epithelial cells and binds two members of the TNFSF, the lymphotoxin alpha/beta (LTA/B) heterotrimers, as well as homotrimeric TNFSF14 (LIGHT) (Rooney et al. 2000, Aggarwal 2003). Both ligands are cytokines produced by activated lymphocytes that plays an important role in the inflammatory and immunologic response. LTA is a product of stimulated T cells and can help elicit cytotoxic effects on cancer cells (Stopfer et al. 2004, Crowe et al. 1994, Mauri et al. 1998, Ware et al. 1992). LTBR (TNFR3) signalling mediates responses controlling cellular differentiation, development and maintenance of peripheral lymphoid organs, dendritic cell homeostasis, hepatic regeneration, interferon responses to pathogens, and death of mucosal derived carcinomas (Norris & Ware 2007, Schneider et al. 2004).

Literature References
PubMed ID Title Journal Year
12387745 The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways

Dejardin, E, Droin, NM, Delhase, M, Haas, E, Cao, Y, Makris, C, Li, ZW, Karin, M, Ware, CF, Green, DR

Immunity 2002
10799510 The lymphotoxin-beta receptor is necessary and sufficient for LIGHT-mediated apoptosis of tumor cells

Rooney, IA, Butrovich, KD, Glass, AA, Borboroglu, S, Benedict, CA, Whitbeck, JC, Cohen, GH, Eisenberg, RJ, Ware, CF

J. Biol. Chem. 2000
9122217 Lymphotoxin-beta receptor signaling complex: role of tumor necrosis factor receptor-associated factor 3 recruitment in cell death and activation of nuclear factor kappaB

VanArsdale, TL, VanArsdale, SL, Force, WR, Walter, BN, Mosialos, G, Kieff, E, Reed, JC, Ware, CF

Proc. Natl. Acad. Sci. U.S.A. 1997
15187124 Lymphotoxin-beta receptor activation by activated T cells induces cytokine release from mouse bone marrow-derived mast cells

Stopfer, P, Männel, DN, Hehlgans, T

J. Immunol. 2004
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Orthologous Events
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