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What is Reactome ?
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phospho-p-S446,T599,S602,S729 BRAF [cytosol]
Stable Identifier
R-MMU-5672676
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
P28028
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
activated RAF homo/heterodimer [cytosol] (Mus musculus)
activated RAF monomer [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:p-2S MAP2K:p-T,Y MAPK complex [endosome membrane] (Mus musculus)
activated RAF homo/heterodimer [cytosol] (Mus musculus)
activated RAF monomer [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Mus musculus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
activated RAF homo/heterodimer [cytosol] (Mus musculus)
activated RAF monomer [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
activated RAF homo/heterodimer [cytosol] (Mus musculus)
activated RAF monomer [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Negative regulation of MAPK pathway (Mus musculus)
PEBP1 binds activated RAF1 (Mus musculus)
p21 RAS:GTP:activated RAF1 homo/heterodimer:PEBP1 [plasma membrane] (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
PP2A dephosphorylates RAF1 (Mus musculus)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
PP5 dephosphorylates RAF1 S338 (Mus musculus)
p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
RAF activation (Mus musculus)
"Activator" RAF:YWHAB dimer binds RAS:GTP (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Phosphorylation of RAF (Mus musculus)
p21 RAS:GTP:activated RAF homo/heterodimer complexes [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Mus musculus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Raf dimer inhibitors bind RAF heterodimers (Mus musculus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
p21RAS:GTP:homo/heterodimerized RAF complex:RAF dimer inhibitors [plasma membrane] (Mus musculus)
p21 RAS:GTP:homo/heterodimerized RAF complex [plasma membrane] (Mus musculus)
p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] (Mus musculus)
'activator' RAF:YWHAB dimer [cytosol] (Mus musculus)
'activator' RAFs [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
Frs2-mediated activation (Mus musculus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
BRAF autophosphorylates downstream of RAP1 and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
Dissociation of phosphorylated MAP2Ks and MAPKs (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:p-2S MAPK2K:p-T,Y MAPK complex [endosome membrane] (Mus musculus)
RAP1:GTP:activated BRAF dimer [endosome membrane] (Mus musculus)
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
phospho-p-S446,T599,S602,S729 BRAF [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P28028
Reference Genes
BioGPS Gene:109880
ENSEMBL:ENSMUSG00000002413
KEGG Gene (Mus musculus):109880
Monarch:109880
NCBI Gene:109880
UCSC:P28028
Reference Transcript
RefSeq:NM_139294.5
Other Identifiers
10544219
106884_at
109880
115053_at
131675_r_at
1425693_at
1435434_at
1456505_at
17466168
4339662
4417087
4472195
4504889
4510831
4519485
4552162
4557996
4583684
4586649
4609352
4806831
4876518
5034297
5063986
5122098
5188225
5206459
5219697
5273038
5275588
5500839
5508612
5515645
5537134
5558269
5566010
5597623
93870_at
A_51_P370226
A_51_P403760
A_52_P39724
A_52_P595117
A_55_P2170787
A_55_P2757886
A_65_P17330
GE102322
GE129436
GO:0000165
GO:0000166
GO:0002318
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004709
GO:0005509
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005975
GO:0006468
GO:0007010
GO:0007155
GO:0007165
GO:0007173
GO:0008152
GO:0008542
GO:0010628
GO:0010764
GO:0010828
GO:0012501
GO:0016020
GO:0016079
GO:0016192
GO:0016301
GO:0016310
GO:0016740
GO:0023052
GO:0030154
GO:0030878
GO:0031267
GO:0031434
GO:0033077
GO:0033138
GO:0034446
GO:0035019
GO:0036211
GO:0042127
GO:0042802
GO:0043005
GO:0043066
GO:0043149
GO:0043226
GO:0043231
GO:0043367
GO:0043368
GO:0043369
GO:0043434
GO:0043524
GO:0044297
GO:0044877
GO:0045580
GO:0046632
GO:0046872
GO:0048538
GO:0048679
GO:0048680
GO:0048856
GO:0048870
GO:0050772
GO:0050852
GO:0050877
GO:0051496
GO:0051591
GO:0055085
GO:0060291
GO:0060323
GO:0060324
GO:0070371
GO:0070374
GO:0070413
GO:0071277
GO:0071466
GO:0072577
GO:0090150
GO:0097110
GO:0098793
GO:0106310
GO:0140096
GO:1900026
GO:1990090
GO:2000301
GO:2000352
ILMN_1252815
ILMN_2418791
ILMN_2435411
Msa.483.0_at
mMC004084
mMC006355
Participates
as a member of
activated RAF monomer [cytosol] (Mus musculus)
as a component of
p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)
as a candidate of
'activator' RAFs [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-S365,S446,S729 BRAF [cytosol]
phospho-hyperphosphorylated BRAF [plasma membrane]
BRAF [cytosol]
phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]
phospho-p-S446,S729-BRAF [cytosol]
Inferred From
p-S446,T599,S602,S729 BRAF [cytosol]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 446 (in Homo sapiens)
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729 (in Homo sapiens)
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599 (in Homo sapiens)
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602 (in Homo sapiens)
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_647455.3
IntEnz
2.7.11.1
Ensembl
ENSMUSP00000002487
,
ENSMUSG00000002413
,
ENSMUST00000002487
PRO
P28028
MGI
88190
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99N57
11
phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-MMU-5672664)
phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-MMU-5672665)
phospho-p-S621-RAF1 [cytosol]
(R-MMU-206028)
phospho-p-Y-RAF1 [cytosol]
(R-MMU-9732747)
RAF1 [cytosol]
(R-MMU-167205)
phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-MMU-5675420)
phospho-p-S621-RAF1 [plasma membrane]
(R-MMU-206222)
phospho-hyperphosphorylated RAF1 [plasma membrane]
(R-MMU-5675193)
phospho-p-S259,S621-RAF1 [cytosol]
(R-MMU-109786)
phospho-p-S338-RAF1 [cytosol]
(R-MMU-5624469)
phospho-p-S338,Y340,Y341-RAF1 [cytosol]
(R-MMU-5624465)
0.589
2
UniProt:P01111 NRAS
20
NRAS [tertiary granule membrane]
(R-HSA-6800190)
NRAS Q61H [plasma membrane]
(R-HSA-9649678)
NRAS G13R [plasma membrane]
(R-HSA-9649672)
NRAS G13V [plasma membrane]
(R-HSA-9649675)
NRAS G13C [plasma membrane]
(R-HSA-9649669)
NRAS G12V [plasma membrane]
(R-HSA-9649666)
NRAS G12C [plasma membrane]
(R-HSA-9649660)
NRAS G12R [plasma membrane]
(R-HSA-9649662)
NRAS G12A [plasma membrane]
(R-HSA-9649657)
NRAS Q61P [plasma membrane]
(R-HSA-9649680)
NRAS Q61R [plasma membrane]
(R-HSA-6802461)
NRAS Q61L [plasma membrane]
(R-HSA-6802455)
NRAS Q61K [plasma membrane]
(R-HSA-6802446)
NRAS G13D [plasma membrane]
(R-HSA-6802363)
NRAS G12S [plasma membrane]
(R-HSA-6802347)
NRAS G12D [plasma membrane]
(R-HSA-6802339)
NRAS Q60E [plasma membrane]
(R-HSA-9656589)
S-Farn-Me NRAS [plasma membrane]
(R-HSA-9647893)
NRAS [plasma membrane]
(R-HSA-62725)
S-Farn-Me PalmS NRAS [Golgi membrane]
(R-HSA-9647906)
0.499
2
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