Reactome | phospho-p-S446,T599,S602,S729 BRAF [cytosol]

phospho-p-S446,T599,S602,S729 BRAF [cytosol]

Stable Identifier

R-MMU-5672676

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

P28028

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P28028

Reference Genes

BioGPS Gene:109880

ENSEMBL:ENSMUSG00000002413

KEGG Gene (Mus musculus):109880

Monarch:109880

NCBI Gene:109880

UCSC:P28028

Reference Transcript

RefSeq:NM_139294.5

Other Identifiers

10544219

106884_at

109880

115053_at

131675_r_at

1425693_at

1435434_at

1456505_at

17466168

4339662

4417087

4472195

4504889

4510831

4519485

4552162

4557996

4583684

4586649

4609352

4806831

4876518

5034297

5063986

5122098

5188225

5206459

5219697

5273038

5275588

5500839

5508612

5515645

5537134

5558269

5566010

5597623

93870_at

A_51_P370226

A_51_P403760

A_52_P39724

A_52_P595117

A_55_P2170787

A_55_P2757886

A_65_P17330

GE102322

GE129436

GO:0000165

GO:0000166

GO:0002318

GO:0002376

GO:0003824

GO:0004672

GO:0004674

GO:0004708

GO:0004709

GO:0005509

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0005975

GO:0006468

GO:0007010

GO:0007155

GO:0007165

GO:0007173

GO:0008152

GO:0008542

GO:0010628

GO:0010764

GO:0010828

GO:0012501

GO:0016020

GO:0016079

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0023052

GO:0030154

GO:0030878

GO:0031267

GO:0031434

GO:0033077

GO:0033138

GO:0034446

GO:0035019

GO:0036211

GO:0042127

GO:0042802

GO:0043005

GO:0043066

GO:0043149

GO:0043226

GO:0043231

GO:0043367

GO:0043368

GO:0043369

GO:0043434

GO:0043524

GO:0044297

GO:0044877

GO:0045580

GO:0046632

GO:0046872

GO:0048538

GO:0048679

GO:0048680

GO:0048856

GO:0048870

GO:0050772

GO:0050852

GO:0050877

GO:0051496

GO:0051591

GO:0055085

GO:0060291

GO:0060323

GO:0060324

GO:0070371

GO:0070374

GO:0070413

GO:0071277

GO:0071466

GO:0072577

GO:0090150

GO:0097110

GO:0098793

GO:0106310

GO:0140096

GO:1900026

GO:1990090

GO:2000301

GO:2000352

ILMN_1252815

ILMN_2418791

ILMN_2435411

Msa.483.0_at

mMC004084

mMC006355

Participates

as a member of

activated RAF monomer [cytosol] (Mus musculus)

as a component of

p-S445,T599,T602,S729 B-Raf complex [cytosol] (Mus musculus)

as a candidate of

'activator' RAFs [cytosol] (Mus musculus)

Other forms of this molecule

phospho-p-S365,S446,S729 BRAF [cytosol]

phospho-hyperphosphorylated BRAF [plasma membrane]

BRAF [cytosol]

phospho-p-S446,T599,S602,S729 BRAF [plasma membrane]

phospho-p-S446,S729-BRAF [cytosol]

Inferred From

p-S446,T599,S602,S729 BRAF [cytosol] (Homo sapiens)

Modified Residues

Name

O-phospho-L-serine at 446 (in Homo sapiens)

Coordinate

446

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 729 (in Homo sapiens)

Coordinate

729

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 599 (in Homo sapiens)

Coordinate

599

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 602 (in Homo sapiens)

Coordinate

602

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_647455.3

IntEnz

2.7.11.1

Ensembl

ENSMUSP00000002487, ENSMUSG00000002413, ENSMUST00000002487

PRO

P28028

MGI

88190

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q99N57	11	phospho-p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-MMU-5672664) phospho-p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5672665) phospho-p-S621-RAF1 [cytosol] (R-MMU-206028) phospho-p-Y-RAF1 [cytosol] (R-MMU-9732747) RAF1 [cytosol] (R-MMU-167205) phospho-p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-MMU-5675420) phospho-p-S621-RAF1 [plasma membrane] (R-MMU-206222) phospho-hyperphosphorylated RAF1 [plasma membrane] (R-MMU-5675193) phospho-p-S259,S621-RAF1 [cytosol] (R-MMU-109786) phospho-p-S338-RAF1 [cytosol] (R-MMU-5624469) phospho-p-S338,Y340,Y341-RAF1 [cytosol] (R-MMU-5624465)	0.589	2
UniProt:P01111 NRAS	20	NRAS [tertiary granule membrane] (R-HSA-6800190) NRAS Q61H [plasma membrane] (R-HSA-9649678) NRAS G13R [plasma membrane] (R-HSA-9649672) NRAS G13V [plasma membrane] (R-HSA-9649675) NRAS G13C [plasma membrane] (R-HSA-9649669) NRAS G12V [plasma membrane] (R-HSA-9649666) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS Q60E [plasma membrane] (R-HSA-9656589) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) NRAS [plasma membrane] (R-HSA-62725) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906)	0.499	2

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