Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
phospho-H2ax [nucleoplasm]
Stable Identifier
R-MMU-5683953
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
p-S140,Y143-H2AFX, P27661
Locations in the PathwayBrowser
Expand all
DNA Repair (Mus musculus)
DNA Double-Strand Break Repair (Mus musculus)
DNA Double Strand Break Response (Mus musculus)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Mus musculus)
APBB1 and MAPK8 bind diphosphorylated H2AFX (Mus musculus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
phospho-H2ax [nucleoplasm] (Mus musculus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome:APBB1:p-T,Y-MAPK8 [nucleoplasm] (Mus musculus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
phospho-H2ax [nucleoplasm] (Mus musculus)
ATM phosphorylates EYA1-4 (Mus musculus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
phospho-H2ax [nucleoplasm] (Mus musculus)
ATM phosphorylates histone H2AFX on S139 at DNA DSBs (Mus musculus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
phospho-H2ax [nucleoplasm] (Mus musculus)
EYA1-4 dephosphorylates tyrosine Y142 of H2AFX (Mus musculus)
DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
phospho-H2ax [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:P27661 H2ax
Gene Names
H2afx, H2a.x, H2ax, Hist5-2ax
Chain
initiator methionine:1, chain:2-143
Reference Genes
BioGPS Gene:15270 H2afx
ENSEMBL:ENSMUSG00000049932 H2afx
KEGG Gene (Mus musculus):15270 H2afx
Monarch:15270 H2afx
NCBI Gene:15270 H2afx
UCSC:P27661 H2afx
Reference Transcript
RefSeq:NM_010436.2 H2afx
Other Identifiers
10403955
10404026
10404045
10408072
10408085
10408094
10408111
10409220
10500324
10584710
1416746_at
15270
17516558
4317557
4377166
4571512
4598206
4670517
4728274
4755297
4925967
4959729
5036590
5078347
5134172
5144850
5246749
5293064
5523296
5549641
93019_at
GO:0000786
GO:0003674
GO:0003677
GO:0005575
GO:0005622
GO:0005694
GO:0032991
GO:0043226
GO:0046982
ILMN_1235873
ILMN_2525581
ILMN_2525595
ILMN_2525605
ILMN_2907878
X58069_s_at
aa269806_s_at
mMC011909
Participates
as a component of
p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] (Mus musculus)
Other forms of this molecule
Histone H2A.x [nucleoplasm]
phospho-H2ax [nucleoplasm]
p-S140-H2afx [nucleoplasm]
phospho-H2ax [nucleoplasm]
Inferred From
p-S140,Y143-H2AFX [nucleoplasm]
(Homo sapiens)
Modified Residues
Name
O-phospho-L-serine at 140
Coordinate
140
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 143 (in Homo sapiens)
Coordinate
143
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_034566.1
Target Pathogen
57c08b76be737e1cc0a95c69
,
57c09037be737e1cc0a96c46
,
57c08b76be737e1cc0a95c6b
Ensembl
ENSMUST00000052686
,
ENSMUSP00000051432
,
ENSMUSG00000049932
PRO
P27661
MGI
102688
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Z0X1 AIFM1
0.556
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text