Reactome | Eme1 [nucleoplasm]

Eme1 [nucleoplasm]

Stable Identifier

R-MMU-5686437

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

EME1, Q8BJW7

Locations in the PathwayBrowser

Expand all

DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - Homology Directed Repair (Mus musculus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
      - HDR through Homologous Recombination (HRR) (Mus musculus)
        
        Resolution of D-Loop Structures (Mus musculus)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Mus musculus)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1 [nucleoplasm] (Mus musculus)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
        
        MUS81 binds EME1, EME2 (Mus musculus)
        
        EME1,EME2 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
        
        MUS81:EME1,EME2 cleaves D-loop (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
        
        SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
- Fanconi Anemia Pathway (Mus musculus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1 [nucleoplasm] (Mus musculus)
        
        Eme1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8BJW7

Gene Names

Eme1

Reference Genes

BioGPS Gene:268465 Eme1

ENSEMBL:ENSMUSG00000039055

KEGG Gene (Mus musculus):268465 Eme1

Monarch:268465 Eme1

NCBI Gene:268465 Eme1

UCSC:Q8BJW7 Eme1

Reference Transcript

RefSeq:NM_177752.4 Eme1

Other Identifiers

10390050

1435054_at

17268031

268465

4319659

4403731

4547066

4603132

4648263

4653832

4901694

4934161

4952152

5003696

5112651

5164213

5215552

5399879

5430077

5612233

A_51_P401263

GO:0000003

GO:0000228

GO:0000278

GO:0000712

GO:0000790

GO:0003674

GO:0003677

GO:0004518

GO:0004519

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005694

GO:0005720

GO:0005730

GO:0006259

GO:0006281

GO:0006302

GO:0006310

GO:0006950

GO:0006974

GO:0007049

GO:0007059

GO:0008150

GO:0009058

GO:0016787

GO:0031297

GO:0031573

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0046872

GO:0048476

GO:0072429

GO:0090305

ILMN_1246446

ILMN_1251679

ILMN_2710968

mMC012719

Participant Of

hasComponent

MUS81:EME1 [nucleoplasm]

hasMember

EME1,EME2 [nucleoplasm]

Inferred From

EME1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_808420.1

Ensembl

ENSMUSG00000039055, ENSMUST00000039949, ENSMUSP00000036361

PRO

Q8BJW7

MGI

3576783

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