Reactome | Eme2 [nucleoplasm]

Eme2 [nucleoplasm]

Stable Identifier

R-MMU-5686438

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

EME2, Q56A04

Locations in the PathwayBrowser

Expand all

DNA Repair (Mus musculus)

- DNA Double-Strand Break Repair (Mus musculus)
  - Homology Directed Repair (Mus musculus)
    - HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) (Mus musculus)
      - HDR through Homologous Recombination (HRR) (Mus musculus)
        
        Resolution of D-Loop Structures (Mus musculus)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Mus musculus)
        
        Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) (Mus musculus)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2),GEN1 [nucleoplasm] (Mus musculus)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
        
        MUS81 binds EME1, EME2 (Mus musculus)
        
        EME1,EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
        
        MUS81:EME1,EME2 cleaves D-loop (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
        
        SLX1A:SLX4 binds MUS81:EME1,(MUS81:EME2) (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
        
        SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
- Fanconi Anemia Pathway (Mus musculus)
  - DNA nucleases bind monoubiquitinated ID2 complex (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Mus musculus)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Mus musculus)
      - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)
    - SLX1A:SLX4:MUS81:EME1,(MUS81:EME2) [nucleoplasm] (Mus musculus)
      - MUS81:EME1, (MUS81:EME2) [nucleoplasm] (Mus musculus)
        
        MUS81:EME2 [nucleoplasm] (Mus musculus)
        
        Eme2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q56A04

Gene Names

Eme2

Reference Genes

BioGPS Gene:193838 Eme2

ENSEMBL:ENSMUSG00000073436

ENSEMBL:ENSMUSG00000073436.12 Eme2

KEGG Gene (Mus musculus):193838 Eme2

Monarch:193838 Eme2

NCBI Gene:193838 Eme2

UCSC:Q56A04 Eme2

Reference Transcript

RefSeq:NM_001163102.1 Eme2

Other Identifiers

10448755

112647_at

1429034_at

17342051

193838

4457514

4521504

4595276

4808245

4910974

4949056

5069712

5343266

A_55_P1965757

GO:0000228

GO:0000278

GO:0000712

GO:0003677

GO:0003824

GO:0004518

GO:0004519

GO:0005634

GO:0005694

GO:0006260

GO:0006281

GO:0006302

GO:0006310

GO:0006974

GO:0007059

GO:0008821

GO:0016787

GO:0022414

GO:0023052

GO:0031297

GO:0031573

GO:0043226

GO:0043596

GO:0048476

GO:0140013

GO:0140097

GO:1905347

ILMN_1224485

mMC012704

Participates

as a candidate of

EME1,EME2 [nucleoplasm] (Mus musculus)

as a component of

MUS81:EME2 [nucleoplasm] (Mus musculus)

Inferred From

EME2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001156574.1

Ensembl

ENSMUSG00000073436, ENSMUSP00000113936, ENSMUST00000121542

PRO

Q56A04

MGI

1919889