Reactome | Ctsz [COPII-coated ER to Golgi transport vesicle]

Ctsz [COPII-coated ER to Golgi transport vesicle]

Stable Identifier

R-MMU-5689727

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

COPII-coated ER to Golgi transport vesicle

Synonyms

(Glc)3(GlcNAc)2(Man)9-CTSZ, Q9WUU7

Locations in the PathwayBrowser

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Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPII-mediated vesicle transport (Mus musculus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPII-mediated vesicle transport (Mus musculus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
      - COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
      - CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
      - Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
      - Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        LMAN receptor:glycosylated cargo [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        Ctsz [COPII-coated ER to Golgi transport vesicle] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9WUU7

Gene Names

Ctsz

Reference Genes

BioGPS Gene:64138 Ctsz

ENSEMBL:ENSMUSG00000016256

ENSEMBL:ENSMUSG00000016256.11 Ctsz

KEGG Gene (Mus musculus):64138 Ctsz

Monarch:64138 Ctsz

NCBI Gene:64138 Ctsz

UCSC:Q9WUU7 Ctsz

Reference Transcript

RefSeq:NM_022325.5 Ctsz

Other Identifiers

10490212

1417868_a_at

1417869_s_at

1417870_x_at

17395155

4329257

4630365

4637319

4784097

5275280

5405082

5437798

5531334

5546273

5613707

64138

92633_at

A_51_P256202

A_52_P62085

GE38185

GO:0003824

GO:0004180

GO:0004197

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005783

GO:0005938

GO:0006508

GO:0008233

GO:0008234

GO:0009986

GO:0010757

GO:0016787

GO:0030163

GO:0030312

GO:0030426

GO:0031012

GO:0031410

GO:0043226

GO:0043231

GO:0048856

GO:0051603

GO:0051604

GO:0060441

GO:0062023

GO:0140096

ILMN_2632785

ILMN_2666007

ILMN_2839569

Msa.3665.0_s_at

mMC003875

mMR027783

Participates

as a member of

glycosylated LMAN cargo [COPII-coated ER to Golgi transport vesicle] (Mus musculus)

Other forms of this molecule

Ctsz [Golgi lumen]

Ctsz [lysosomal lumen]

Ctsz [plasma membrane]

Ctsz [specific granule lumen]

Ctsz [extracellular region]

Ctsz [ficolin-1-rich granule lumen]

Ctsz [endoplasmic reticulum-Golgi intermediate compartment membrane]

Ctsz [endoplasmic reticulum lumen]

Inferred From

(Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle] (Homo sapiens)

Modified Residues

Name

N4-(N-acetylamino)glucosyl-L-asparagine (N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-L-Asn residue (ChEBI:59084)) at unknown position

Modification

N-{alpha-Glc-(1->2)-alpha-Glc-(1->3)-alpha-Glc-(1->3)-alpha-Man-(1->2)-alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->3)-(alpha-Man-(1->2)-alpha-Man-(1->6))-alpha-Man-(1->6))-beta-Man-(1->4)-beta-GlcNAc-(1->4)-beta-GlcNAc}-yl group (ChEBI:59084)

PsiMod Name

N4-(N-acetylamino)glucosyl-L-asparagine

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.

Cross References

RefSeq

NP_071720.1

IntEnz

3.4.18.1

Ensembl

ENSMUST00000016400, ENSMUSP00000016400, ENSMUSG00000016256

PRO

Q9WUU7

MGI

1891190

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