Reactome | Cd59b [ER to Golgi transport vesicle membrane]

Cd59b [ER to Golgi transport vesicle membrane]

Stable Identifier

R-MMU-5689801

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

ER to Golgi transport vesicle membrane

Synonyms

GPI-CD59, P58019

Locations in the PathwayBrowser

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Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Asparagine N-linked glycosylation (Mus musculus)
    - Transport to the Golgi and subsequent modification (Mus musculus)
      - ER to Golgi Anterograde Transport (Mus musculus)
        
        COPII-mediated vesicle transport (Mus musculus)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)

Vesicle-mediated transport (Mus musculus)

- Membrane Trafficking (Mus musculus)
  - ER to Golgi Anterograde Transport (Mus musculus)
    - COPII-mediated vesicle transport (Mus musculus)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
      - COPII coat binds TRAPPCII and RAB1:GDP (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
      - CSNK1D phosphorylates SEC23 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:v:SNAREs:GOLGA2:GORASP1:USO1 homodimer [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
      - Nucleotide exchange on RAB1 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GDP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
      - RAB1:GTP binds USO1 and GORASP1:GOLGA2 (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP:USO1 homodimer:GOLGA2:GORASP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs:TRAPPCII:RAB1:GTP [COPII-coated ER to Golgi transport vesicle] (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)
      - Vesicle budding (Mus musculus)
        
        COPII cargo:receptors:SEC23:SEC24:SEC13:SEC31:SEC23IP:v-SNAREs [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        COPII cargo:receptors [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        TMED2:TMED10 tetramer:GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)
        
        Cd59b [ER to Golgi transport vesicle membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P58019

Gene Names

Cd59b

Reference Genes

BioGPS Gene:333883 Cd59b

CTD Gene:333883 Cd59b

ENSEMBL:ENSMUSG00000068686

KEGG Gene (Mus musculus):333883 Cd59b

Monarch:333883 Cd59b

NCBI Gene:333883 Cd59b

UCSC:P58019 Cd59b

Reference Transcript

Other Identifiers

100293_at

101516_at

10474223

1418710_at

17373817

333883

4670725

4997214

5056316

5389079

5416304

5438513

5468627

5491431

AA690006_at

A_51_P142896

A_52_P232693

A_52_P61691

A_55_P1995404

GE1560144

GE33486

GO:0001848

GO:0001971

GO:0002376

GO:0005576

GO:0005615

GO:0005886

GO:0007155

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0042102

GO:0042383

GO:0043066

GO:0043218

GO:0045916

GO:1903660

ILMN_1228942

ILMN_2650300

ILMN_2660766

ILMN_2792143

mMR028870

Participates

as a member of

GPI-CD59, GPI-FOLR1 [ER to Golgi transport vesicle membrane] (Mus musculus)

Other forms of this molecule

Cd59b [tertiary granule membrane]

Cd59b [specific granule membrane]

Cd59b [Golgi membrane]

Cd59b [transport vesicle]

Cd59b [endoplasmic reticulum-Golgi intermediate compartment membrane]

Cd59b [endoplasmic reticulum membrane]

Cd59b [plasma membrane]

Inferred From

GPI-CD59 [ER to Golgi transport vesicle membrane] (Homo sapiens)

Modified Residues

Name

L-asparagine amide (GPI-anchor amidated amino acid carboxyl end residue(1−)) at 102 (in Homo sapiens)

Coordinate

102

Modification

GPI-anchor amidated amino acid carboxyl end residue(1−)

PsiMod Name

L-asparagine amide

PsiMod Definition

A protein modification that effectively converts an L-asparagine residue to L-asparagine amide.

Cross References

RefSeq

NP_862906.1, XP_006499866.1, XP_006499868.1, XP_006499865.1, XP_006499867.1

Ensembl

ENSMUST00000129749, ENSMUSP00000117553, ENSMUSP00000087912, ENSMUSP00000106760, ENSMUST00000111130, ENSMUSG00000068686, ENSMUST00000090429

PRO

P58019

MGI

1888996

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