NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes

Stable Identifier
R-MMU-573383
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes

Cytosine residues in the main promoter of silenced rRNA gene copies are methylated by Dnmt1 and Dnmt3b (Santoro et al. 2002, Santoro and Grummt 2005). Dnmt3b directly binds a triple helix formed by pRNA and the main promoter of rDNA (Schmitz et al. 2010). The methylated cytosines prevent binding of the UBF transcription factor, thus preventing transcription of silenced rRNA gene copies (Santoro and Grummt 2001). Histone deacetylation is required for DNA methylation (Santoro et al. 2005)

Participants
Catalyst Activity
Catalyst Activity
Title
DNA-methyltransferase activity of NoRC:pRNA:Hdac:Dnmt [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created