NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes

Stable Identifier
R-MMU-573383
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
High
 | PPTX  | SBGN
NoRC:intergenic spacer:Hdac:Dnmt complex methylates cytosine in the rRNA genes
Cytosine residues in the main promoter of silenced rRNA gene copies are methylated by Dnmt1 and Dnmt3b (Santoro et al. 2002, Santoro and Grummt 2005). Dnmt3b directly binds a triple helix formed by pRNA and the main promoter of rDNA (Schmitz et al. 2010). The methylated cytosines prevent binding of the UBF transcription factor, thus preventing transcription of silenced rRNA gene copies (Santoro and Grummt 2001). Histone deacetylation is required for DNA methylation (Santoro et al. 2005)
Literature References
Participants
Input
Output
Catalyst Activity

DNA-methyltransferase activity of NoRC:pRNA:Hdac:Dnmt [nucleoplasm]

Physical Entity
NoRC:pRNA:Hdac:Dnmt [nucleoplasm] (Mus musculus)
Activity
DNA-methyltransferase activity (GO:0009008)
Orthologous Events
NoRC:HDAC:DNMT methylates cytosine of the rRNA genes (Homo sapiens)
Authored
May, B  (2010-04-06)
Reviewed
Shiao, YH  (2014-02-18)
Created
May, B  (2010-04-10)
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