Reactome | Prkar2a [cytosol]

Prkar2a [cytosol]

Stable Identifier

R-MMU-57840

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

PRKAR2A, P12367

Locations in the PathwayBrowser

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Metabolism (Mus musculus)

- Integration of energy metabolism (Mus musculus)
  - Glucagon signaling in metabolic regulation (Mus musculus)
    - PKA activation in glucagon signalling (Mus musculus)
      - cAMP induces dissociation of inactive PKA tetramers (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP:PKA regulatory subunit [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)

Neuronal System (Mus musculus)

- Transmission across Chemical Synapses (Mus musculus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Mus musculus)
    - Activation of NMDA receptors and postsynaptic events (Mus musculus)
      - Post NMDA receptor activation events (Mus musculus)
        
        CREB1 phosphorylation through the activation of Adenylate Cyclase (Mus musculus)
        
        cAMP binds PKA tetramer (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP induces dissociation of inactive PKA tetramers (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP:PKA regulatory subunit [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)

Signal Transduction (Mus musculus)

- Intracellular signaling by second messengers (Mus musculus)
  - DAG and IP3 signaling (Mus musculus)
    - CaM pathway (Mus musculus)
      - Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        cAMP binds PKA tetramer (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP induces dissociation of inactive PKA tetramers (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP:PKA regulatory subunit [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Opioid Signalling (Mus musculus)
        
        DARPP-32 events (Mus musculus)
        
        cAMP binds PKA tetramer (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP induces dissociation of inactive PKA tetramers (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP:PKA regulatory subunit [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        G-protein mediated events (Mus musculus)
        
        PLC beta mediated events (Mus musculus)
        
        Ca-dependent events (Mus musculus)
        
        CaM pathway (Mus musculus)
        
        Calmodulin induced events (Mus musculus)
        
        PKA-mediated phosphorylation of CREB (Mus musculus)
        
        PKA activation (Mus musculus)
        
        cAMP binds PKA tetramer (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP induces dissociation of inactive PKA tetramers (Mus musculus)
        
        PKA tetramer:4xcAMP [cytosol] (Mus musculus)
        
        PKA tetramer [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)
        
        cAMP:PKA regulatory subunit [cytosol] (Mus musculus)
        
        PKA regulatory subunit [cytosol] (Mus musculus)
        
        Prkar2a [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P12367 Prkar2a

Gene Names

Prkar2a

Chain

initiator methionine:1, chain:2-401

Participant Of

hasMember

PKA regulatory subunit [cytosol]

Other forms of this molecule

Prkar2a [cytosol]

Prkar2a [ciliary base]

Inferred From

PRKAR2A [cytosol] (Homo sapiens)

Cross References

PRO

P12367

MGI

108025

PDB

1KMW, 3J4Q, 1KMU, 3J4R, 1R2A, 1L6E, 2QVS, 2IZY

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:D3YVF0 Akap5	3	Akap5 [plasma membrane] (R-MMU-381669) Akap5 [plasma membrane] (R-MMU-9010693) Akap5 [cytosol] (R-MMU-416331)	0.499	2
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.462	2

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