Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
MAP2K2 [cytosol]
Stable Identifier
R-MMU-59504
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
Q63932
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2Ks and MAPKs are phosphorylated at the endosome membrane (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3 binds MAPK components (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
WDR83:LAMTOR2:LAMTOR3:activated RAF:MAP2K:MAPK complex [endosome membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Prolonged ERK activation events (Mus musculus)
Frs2-mediated activation (Mus musculus)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
RAP1:GTP:activated BRAF dimer:MAPK2K:MAPK complex [endosome membrane] (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF (Mus musculus)
MAP2K homo/heterodimers [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q63932
Reference Genes
BioGPS Gene:26396
ENSEMBL:ENSMUSG00000035027
KEGG:mmu:26396
Monarch:26396
NCBI Gene:26396
UCSC:Q63932
Reference Transcript
RefSeq:NM_023138.5
Other Identifiers
10364971
1415974_at
1460636_at
17235539
26396
4330615
4348296
4403855
4445456
4449387
4495740
4694580
4711201
4854862
4888490
5027163
5093134
5144463
5190085
5200276
5206226
5235426
5236066
5389576
5402585
5425531
5457116
5491694
5527898
92543_at
A_51_P439626
A_55_P2152292
A_55_P2716627
A_55_P2716631
A_55_P2757581
GE40374
GO:0000165
GO:0002931
GO:0003824
GO:0004672
GO:0004674
GO:0004708
GO:0004712
GO:0004713
GO:0005078
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005739
GO:0005768
GO:0005769
GO:0005770
GO:0005783
GO:0005794
GO:0005829
GO:0005874
GO:0005911
GO:0005925
GO:0005938
GO:0006355
GO:0006468
GO:0007507
GO:0009898
GO:0010628
GO:0010629
GO:0014044
GO:0016020
GO:0016301
GO:0016740
GO:0030165
GO:0030878
GO:0031410
GO:0032872
GO:0038133
GO:0042552
GO:0043226
GO:0043539
GO:0045893
GO:0046872
GO:0048009
GO:0048471
GO:0048538
GO:0048679
GO:0048856
GO:0050772
GO:0060090
GO:0060324
GO:0060425
GO:0060440
GO:0060502
GO:0070371
GO:0090170
GO:0097110
GO:0098772
GO:0106310
GO:0140096
GO:2000147
GO:2000641
ILMN_1258682
ILMN_2884050
Msa.5815.0_s_at
Msa.7301.0_s_at
aa472313_s_at
mMC005618
Participates
as a component of
MAP2K2 dimer [cytosol] (Mus musculus)
MAP2K1:MAPK2K2 heterodimer [cytosol] (Mus musculus)
Other forms of this molecule
phospho-p-S,T-MAP2K2 [cytosol]
phospho-p-S222,S226-MAP2K2 [cytosol]
Inferred From
MAP2K2 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_075627.2
ENSEMBL
ENSMUST00000143517
,
ENSMUSP00000121111
IntEnz
2.7.12.2
PRO
Q63932
MGI
1346867
PDB
1JKY
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.628
12
UniProt:Q8CGE9
1
Rgs12 [plasma membrane]
(R-MMU-939784)
0.593
3
UniProt:P85298-4 ARHGAP8
0.537
5
UniProt:P35438 Grin1
3
Grin1 [plasma membrane]
(R-MMU-3928395)
Grin1 [endoplasmic reticulum membrane]
(R-MMU-9610359)
Grin1 [transport vesicle membrane]
(R-MMU-9610566)
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text