Reactome | Ndufa2 [mitochondrial inner membrane]

Ndufa2 [mitochondrial inner membrane]

Stable Identifier

R-MMU-60178

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

mitochondrial inner membrane

Synonyms

NDUFA2, Q9CQ75

Locations in the PathwayBrowser

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Metabolism (Mus musculus)

- The citric acid (TCA) cycle and respiratory electron transport (Mus musculus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Mus musculus)
    - Respiratory electron transport (Mus musculus)
      - Complex I biogenesis (Mus musculus)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        HP subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        Ndufa2 [mitochondrial inner membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9CQ75

Gene Names

Ndufa2

Reference Genes

BioGPS Gene:17991 Ndufa2

ENSEMBL:ENSMUSG00000014294

ENSEMBL:ENSMUSG00000014294 Ndufa2

KEGG Gene (Mus musculus):17991 Ndufa2

Monarch:17991 Ndufa2

NCBI Gene:17991 Ndufa2

UCSC:Q9CQ75 Ndufa2

Reference Transcript

RefSeq:NM_010885.5 Ndufa2

Other Identifiers

10458386

1417368_s_at

17353752

17991

5036879

5065199

5174921

5226771

5235093

5451403

96280_at

A_51_P384946

GE119146

ILMN_2588601

mMC021470

Participates

as a component of

HP subcomplex [mitochondrial inner membrane] (Mus musculus)

Inferred From

NDUFA2 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_035015.2

Ensembl

ENSMUST00000014438, ENSMUSP00000014438, ENSMUSG00000014294

PRO

Q9CQ75

MGI

1343103

PDB

6G72, 6ZR2, 6G2J, 6ZTQ

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63101 Ywhaz	3	Ywhaz [nucleoplasm] (R-MMU-450469) Ywhaz [cytosol] (R-MMU-206099) 14-3-3zeta [cytosol] (R-MMU-206177)	0.527	2

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