Reactome | mt-Nd2 [mitochondrial inner membrane]

mt-Nd2 [mitochondrial inner membrane]

Stable Identifier

R-MMU-60553

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

mitochondrial inner membrane

Synonyms

MT-ND2, P03893

Locations in the PathwayBrowser

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Metabolism (Mus musculus)

- Aerobic respiration and respiratory electron transport (Mus musculus)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Mus musculus)
    - Respiratory electron transport (Mus musculus)
      - Complex I biogenesis (Mus musculus)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Mus musculus)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Mus musculus)
        
        980kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Mus musculus)
        
        Complex I [mitochondrial inner membrane] (Mus musculus)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Mus musculus)
        
        370 kDa subcomplex (-MCIA complex) [mitochondrial inner membrane] (Mus musculus)
        
        COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)
        
        mt-Nd2 [mitochondrial inner membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P03893

Gene Names

mt-Nd2

Reference Genes

BioGPS Gene:17717 mt-Nd2

ENSEMBL:ENSMUSG00000064345

ENSEMBL:ENSMUSG00000064345.1 mt-Nd2

KEGG Gene (Mus musculus):17717 mt-Nd2

Monarch:17717 mt-Nd2

NCBI Gene:17717 mt-Nd2

Reference Transcript

RefSeq:NC_005089.1 mt-Nd2

Other Identifiers

10598032

10598034

17532605

17532607

17532609

17550528

17550530

17550590

17550591

17550594

17550595

17717

4426342

4590601

4830390

4900995

4928685

4932305

4970313

5084279

5219393

5226822

5413539

5504406

5595650

A_55_P2039110

GO:0003824

GO:0005215

GO:0005739

GO:0005743

GO:0005747

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0009060

GO:0016020

GO:0016491

GO:0019901

GO:0032981

GO:0035255

GO:0042776

GO:0043226

GO:0055086

GO:0065003

GO:0070469

GO:0072593

GO:1901135

ILMN_1229560

ILMN_2434853

Participates

as a component of

COA1:MT-ND2 [mitochondrial inner membrane] (Mus musculus)

Inferred From

MT-ND2 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_904329.1

IntEnz

7.1.1.2

Ensembl

ENSMUST00000082396, ENSMUSG00000064345, ENSMUSP00000080992

PRO

P03893

MGI

102500

PDB

7AK5, 7AK6, 7PSA, 6G2J, 6ZTQ, 8OLT, 6G72, 6ZR2, 8OM1, 7B93

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