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About
What is Reactome ?
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Sos1 [cytosol]
Stable Identifier
R-MMU-64847
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
SOS1, Q62245
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
NCAM signaling for neurite out-growth (Mus musculus)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
RET signaling (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB2-1:SOS1 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1 binds GRB2-1:SOS1 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
Tie2 Signaling (Mus musculus)
Interaction of SOS-1 to Tie2 bound Grb2 (Mus musculus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) (Mus musculus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Adaptive Immune System (Mus musculus)
Signaling by the B Cell Receptor (BCR) (Mus musculus)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Mus musculus)
p-6Y-SYK phosphorylates BLNK (SLP65) (Mus musculus)
BLNK:GRB2:SOS1:CIN85 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
FLT3 Signaling (Mus musculus)
Active FLT3:GRB2 binds SOS1 (Mus musculus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS1-mediated nucleotide exchange of RAS downstream of FLT3 (Mus musculus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Interleukin-15 signaling (Mus musculus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Mus musculus)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Mus musculus)
SOS1, SOS2 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS1, SOS2 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
Interleukin receptor SHC signaling (Mus musculus)
Phosphorylated SHC recruits GRB2:SOS1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Innate Immune System (Mus musculus)
DAP12 interactions (Mus musculus)
DAP12 signaling (Mus musculus)
Activation of RAC1 by VAV2/3 (Mus musculus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation and activation of VAV2/VAV3 by SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation of BTK by p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-SYK/p-BTK [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation of SLP-76 by p-SYK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of VAV and BTK to p-SLP-76 (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Release of p-PLCG1 (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Fc epsilon receptor (FCERI) signaling (Mus musculus)
FCERI mediated Ca+2 mobilization (Mus musculus)
Autophosphorylation of BTK/ITK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Hydrolysis of PIP2 by PLCG (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation of TEC kinases by p-SYK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
FCERI mediated MAPK activation (Mus musculus)
Activation of RAC1 by VAV (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Autophosphorylation of PAK (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Interaction of GRB2:SOS complex with p-SHC1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation and activation of VAV (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation of SLP-76 by p-SYK (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of GADS:SLP-76 to p-5Y-LAT (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of GRB2:SOS to p-5Y-LAT (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of PAK to the membrane by binding active RAC1 (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Mus musculus)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of PLC-gamma to SLP-76 and p-5Y-LAT (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:SLP76 [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of VAV to p-SLP-76 (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS mediated nucleotide exchange of RAS (SHC) (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Role of LAT2/NTAL/LAB on calcium mobilization (Mus musculus)
PI3K associates with phosphorylated GAB2 (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Phosphorylation of PIP2 to PIP3 by PI3K (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2:PI3K [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS:p-3Y-GAB2 [plasma membrane] (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of GRB2:SOS to p-10Y-NTAL (Mus musculus)
p-10Y-NTAL:p-SHC1:GRB2:SOS [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
p75 NTR receptor-mediated signalling (Mus musculus)
Cell death signalling via NRAGE, NRIF and NADE (Mus musculus)
NRAGE signals death through JNK (Mus musculus)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Mus musculus)
GEFs [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Integrin signaling (Mus musculus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:p-Y349,Y350,Y427-SHC1:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
EGF:p-EGFR:p-ERBB2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
p-SHC1:GRB2:SOS [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by GPCR (Mus musculus)
GPCR downstream signalling (Mus musculus)
G alpha (12/13) signalling events (Mus musculus)
GEFs activate RhoA,B,C (Mus musculus)
GEFs [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
G alpha (q) signalling events (Mus musculus)
Gastrin-CREB signalling pathway via PKC and MAPK (Mus musculus)
EGFR Transactivation by Gastrin (Mus musculus)
GRB2:SOS1 binds to HBEGF:p-Y-EGFR (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) (Mus musculus)
GRB2:SOS1:HB-EGF:p-6Y-EGFR [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
GRB2 events in EGFR signaling (Mus musculus)
GRB2-1 binds SOS1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1 complex binds to EGF:EGFR complex (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SHC1 events in EGFR signaling (Mus musculus)
GRB2:SOS1 binds to phosphorylated SHC1 in complex with EGFR (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) (Mus musculus)
EGF-like ligands:p-6Y-EGFR:p-Y349,350-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by ERBB2 (Mus musculus)
GRB2 events in ERBB2 signaling (Mus musculus)
GRB2:SOS1 complex binds phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers (Mus musculus)
NRGs/EGFLs:p-ERBB4:p-ERBB2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by ERBB4 (Mus musculus)
SHC1 events in ERBB4 signaling (Mus musculus)
RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by FGFR (Mus musculus)
Signaling by FGFR1 (Mus musculus)
Downstream signaling of activated FGFR1 (Mus musculus)
FRS-mediated FGFR1 signaling (Mus musculus)
Activated FGFR1:p-FRS binds GRB2:SOS1 (Mus musculus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR1:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SHC-mediated cascade:FGFR1 (Mus musculus)
Activated FGFR1:p-SHC1 binds GRB2:SOS1 (Mus musculus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR1:p-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by FGFR2 (Mus musculus)
Downstream signaling of activated FGFR2 (Mus musculus)
FRS-mediated FGFR2 signaling (Mus musculus)
Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR2:pFRS binds GRB2:SOS1 (Mus musculus)
Activated FGFR2:p-FRS:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SHC-mediated cascade:FGFR2 (Mus musculus)
Activated FGFR2:p-SHC1 binds GRB2:SOS1 (Mus musculus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR2:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by FGFR3 (Mus musculus)
Downstream signaling of activated FGFR3 (Mus musculus)
FRS-mediated FGFR3 signaling (Mus musculus)
Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR3:pFRS binds GRB2:SOS1 (Mus musculus)
Activated FGFR3:p-FRS:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SHC-mediated cascade:FGFR3 (Mus musculus)
Activated FGFR3:p-SHC1 binds GRB2:SOS1 (Mus musculus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR3:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by FGFR4 (Mus musculus)
Downstream signaling of activated FGFR4 (Mus musculus)
FRS-mediated FGFR4 signaling (Mus musculus)
Activated FGFR4:p-FRS binds GRB2:SOS1 (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR4:p-FRS2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SHC-mediated cascade:FGFR4 (Mus musculus)
Activated FGFR4:p-SHC1 binds GRB2:SOS1 (Mus musculus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange (Mus musculus)
Activated FGFR4:pY-SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
GRB2-1 binds SOS1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 binds p-Y427-SHC1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
IRS-mediated signalling (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signal attenuation (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1 (Mus musculus)
GRB2-1:SOS1:p-Y427-SHC1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by LTK (Mus musculus)
Active LTK recruits GRB2:SOS1 (Mus musculus)
Active LTK:p-3Y SHC1:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by MET (Mus musculus)
MET activates RAS signaling (Mus musculus)
Activated MET binds RANBP9 and SOS1 (Mus musculus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Activated MET recruits GRB2-1:SOS1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
HGF:p-4Y-MET dimer:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET (Mus musculus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SHC1-2 bound to MET recruits GRB2:SOS1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
HGF:p-4Y-MET dimer:p-Y317-SHC1-2:GRB2:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
Signalling to ERKs (Mus musculus)
Signalling to RAS (Mus musculus)
GRB2-1:SOS1 binds p-Y-SHC (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-Y-SHC [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by NTRK2 (TRKB) (Mus musculus)
Activated NTRK2 signals through FRS2 and FRS3 (Mus musculus)
NTRK2-phosphorylated FRS2 binds GRB2 (Mus musculus)
BDNF,NTF4:p-5Y-NTRK2:p-Y-FRS2:GRB2-1:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by PDGF (Mus musculus)
Downstream signal transduction (Mus musculus)
GRB2:SOS1 complex binds to the active receptor (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) (Mus musculus)
PDGF:Phospho-PDGF receptor dimer:Grb2:Sos1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by SCF-KIT (Mus musculus)
Activation of RAS by p-KIT bound SOS1 (Mus musculus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS interacts with p-KIT (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Regulation of KIT signaling (Mus musculus)
Recruitment of CBL to KIT (Mus musculus)
CBL:Grb2/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Grb2:SOS:p-c-Kit/p-APS:p-c-Kit complex [plasma membrane] (Mus musculus)
GRB2:SOS1:p-KIT complex [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
SHC-related events triggered by IGF1R (Mus musculus)
GRB2-1:SOS1 binds p-3Y-SHC1 (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
GRB2-1:SOS1:p-3Y-SHC1 [cytosol] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Mus musculus)
Signaling by Rho GTPases (Mus musculus)
RHO GTPase cycle (Mus musculus)
RAC1 GTPase cycle (Mus musculus)
RAC1 GEFs activate RAC1 (Mus musculus)
RAC1 GEFs [cytosol] (Mus musculus)
Sos1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:Q62245 Sos1
Gene Names
Sos1
Chain
chain:1-1319
Reference Genes
BioGPS Gene:20662 Sos1
KEGG:mmu:20662 Sos1
Monarch:20662 Sos1
NCBI Gene:20662 Sos1
UCSC:Q62245 Sos1
Reference Transcript
RefSeq:NM_009231.2 Sos1
Other Identifiers
10453141
112449_at
1421884_at
1421885_at
1421886_at
1434389_at
160911_at
17347533
20662
4305177
4350021
4380164
4403196
4414894
4472863
4479945
4614931
4615682
4634565
4660293
4664066
4701723
4734575
4768134
4804663
4858618
4896441
4911288
4957355
4977665
5039201
5095191
5105634
5147425
5158144
5276979
5292116
5309269
5323713
5441405
5466247
5504101
5552064
A_51_P125792
A_52_P341339
A_55_P2935600
GE33702
GO:0001782
GO:0001942
GO:0002260
GO:0002376
GO:0002931
GO:0003007
GO:0003209
GO:0003344
GO:0005085
GO:0005154
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0006355
GO:0006357
GO:0007173
GO:0007264
GO:0007265
GO:0007296
GO:0008286
GO:0008543
GO:0014044
GO:0014069
GO:0017124
GO:0019901
GO:0033081
GO:0035264
GO:0038133
GO:0042110
GO:0042127
GO:0042129
GO:0042552
GO:0043025
GO:0043226
GO:0045742
GO:0046579
GO:0046982
GO:0048009
GO:0048011
GO:0048514
GO:0048856
GO:0050853
GO:0051057
GO:0060021
GO:0060090
GO:0061029
GO:0061384
GO:0098772
GO:0098978
GO:0140693
GO:1904693
GO:1905360
GO:2000973
ILMN_2737338
Z11574_s_at
mMR029373
Participates
as a candidate of
RAC1 GEFs [cytosol] (Mus musculus)
SOS1, SOS2 [cytosol] (Mus musculus)
as an input of
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
Active FLT3:GRB2 binds SOS1 (Mus musculus)
SOS binds Grb2 bound to pFAK:NCAM1 (Mus musculus)
Activated MET binds RANBP9 and SOS1 (Mus musculus)
Interaction of SOS-1 to Tie2 bound Grb2 (Mus musculus)
GRB2-1 binds SOS1 (Mus musculus)
as a component of
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
BLNK:GRB2:SOS1:CIN85 [cytosol] (Mus musculus)
pFAK:Grb2:Sos [cytosol] (Mus musculus)
SOS-1 bound to Tie2:Grb2 [plasma membrane] (Mus musculus)
Active FLT3:GRB2:SOS1 [plasma membrane] (Mus musculus)
HGF:p-4Y-MET dimer:RANBP9:SOS1 [plasma membrane] (Mus musculus)
GRB2-1:SOS1 [cytosol] (Mus musculus)
as a member of
GEFs [cytosol] (Mus musculus)
Other forms of this molecule
phospho-Sos1 [cytosol]
Sos1 [cytosol]
Sos1 [plasma membrane]
Inferred From
SOS1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_033257.2
ENSEMBL
ENSMUSP00000067786
,
ENSMUST00000068714
PRO
Q62245
MGI
98354
PDB
1B07
,
4GBQ
,
2GBQ
,
3GBQ
,
1PMS
,
1GBQ
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
1
Grb2 [cytosol]
(R-MMU-443287)
0.757
7
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.704
4
UniProt:P62993-1 GRB2
2
GRB2-1 [cytosol]
(R-HSA-74686)
GRB2-1 [plasma membrane]
(R-HSA-202993)
0.558
2
UniProt:P26663 POLG
0.558
2
UniProt:P29355
1
sem-5 [cytosol]
(R-CEL-74686)
0.558
2
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