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Fas [plasma membrane]
Stable Identifier
R-MMU-66248
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
plasma membrane
Synonyms
FAS, P25446
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Mus musculus)
Apoptosis (Mus musculus)
Caspase activation via extrinsic apoptotic signalling pathway (Mus musculus)
Caspase activation via Death Receptors in the presence of ligand (Mus musculus)
Dimerization of procaspase-8 (Mus musculus)
FAS-mediated dimerization of procaspase-8 (Mus musculus)
FASL:FAS receptor trimer:FADD:procaspase-8-dimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
Regulation by c-FLIP (Mus musculus)
Caspase-8 and FLIP(L) processing at DISC (Mus musculus)
DISC:p43/p41CASP8:p43 FLIP(L) [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer in FasL/CD95 signaling (Mus musculus)
FASL:FAS Receptor Trimer:FADD:pro-Caspase-8:FLIP(L) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
Regulated Necrosis (Mus musculus)
RIPK1-mediated regulated necrosis (Mus musculus)
Regulation of necroptotic cell death (Mus musculus)
CASP8 activity is inhibited (Mus musculus)
FLIP(L) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
DISC:procaspase-8:FLIP(L) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FLIP(S) and procaspase-8 form heterodimer (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
DISC:procaspase-8:FLIP(S) [plasma membrane] (Mus musculus)
DISC:procaspase-8 [plasma membrane] (Mus musculus)
DISC [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
Signal Transduction (Mus musculus)
Death Receptor Signaling (Mus musculus)
FasL/ CD95L signaling (Mus musculus)
FASL binds FAS Receptor (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD complex binds pro-Caspase-8 (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FASL:FAS trimer:FADD:CASP8(1-479) [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FasL:Fas binds FADD (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer:FADD [plasma membrane] (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
Trimerization of the FASL:FAS receptor complex (Mus musculus)
FASL:FAS Receptor Trimer [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Fas [plasma membrane] (Mus musculus)
External Reference Information
External Reference
UniProt:P25446
Gene Names
Fas
Reference Genes
ENSEMBL:ENSMUSG00000024778
UCSC:P25446 Fas
Other Identifiers
102921_s_at
10462603
14102
1460251_at
17358797
4326956
4395329
4398804
4546052
4681942
4770953
4808962
4835083
4870799
4907762
4944618
4970048
5040828
5102581
5259408
5417758
5544906
AFFX-MurFAS_at
A_51_P345393
A_52_P73385
FAS_at
GE34378
GO:0002376
GO:0004888
GO:0005031
GO:0005515
GO:0005516
GO:0005576
GO:0005886
GO:0006915
GO:0006924
GO:0006925
GO:0006955
GO:0007165
GO:0007623
GO:0008625
GO:0009636
GO:0009897
GO:0009986
GO:0010467
GO:0016020
GO:0019724
GO:0031265
GO:0031334
GO:0032872
GO:0033209
GO:0042802
GO:0042981
GO:0043029
GO:0043066
GO:0045060
GO:0045121
GO:0045577
GO:0045580
GO:0045637
GO:0048536
GO:0048856
GO:0050869
GO:0051241
GO:0051384
GO:0051402
GO:0070227
GO:0071248
GO:0071285
GO:0090200
GO:0097049
GO:0097190
GO:0097191
GO:0097192
GO:0097284
GO:0097527
GO:1901532
ILMN_2454420
ILMN_2479290
ILMN_2582933
ILMN_2582940
ILMN_2902979
M83649_s_at
mMC008894
Participates
as an input of
FASL binds FAS Receptor (Mus musculus)
as a component of
FASL:FAS Receptor monomer [plasma membrane] (Mus musculus)
Inferred From
FAS [plasma membrane]
(Homo sapiens)
Cross References
ENSEMBL
ENSMUSP00000025691
,
ENSMUST00000025691
,
ENSMUSG00000024778
PRO
P25446
GlyGen
P25446
MGI
95484
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.772
8
UniProt:O89110
6
Casp8 [cytosol]
(R-MMU-3465404)
Casp8 [mitochondrial outer membrane]
(R-MMU-351869)
Casp8 [mitochondrial outer membrane]
(R-MMU-351828)
Casp8 [cytosol]
(R-MMU-76158)
Casp8 [cytosol]
(R-MMU-75975)
Casp8 [cytosol]
(R-MMU-57031)
0.669
3
UniProt:Q61160
1
Fadd [cytosol]
(R-MMU-54639)
0.669
3
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.635
4
UniProt:O35613
2
Daxx [nucleoplasm]
(R-MMU-4086086)
Daxx [nucleoplasm]
(R-MMU-3222068)
0.589
2
UniProt:Q9ERH7 HIPK3
0.508
3
UniProt:P54731 FAF1
0.508
2
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