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Vwf [extracellular region]
Stable Identifier
R-MMU-67271
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
extracellular region
Synonyms
VWF(23-763), Q8CIZ8
Locations in the PathwayBrowser
Expand all
Hemostasis (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
GP1b-IX-V activation signalling (Mus musculus)
GP1b signaling involves c-Src (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GP1b-IX-V binds 14-3-3-zeta (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GP1b-IX-V binds filamin (Mus musculus)
GPIb-IX-V:vWF:filamin-A [plasma membrane] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GP1b-IX-V:13-3-3-zeta complexes with p85 PI3K (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GPIb-IX-V:vWF:14-3-3-zeta:p85 [plasma membrane] (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GPIb-IX-V binding to 14-3-3 zeta is reduced by shear stress (Mus musculus)
GPIb-IX-V:Collagen type I fibril:vWF:14-3-3-zeta [plasma membrane] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GPIb-IX-V binds to vWF:Collagen complex (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
vWF binds to collagen (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Thrombin binding to GP1b:IX:V (Mus musculus)
GP1b-IX-V complex:activated thrombin (factor IIa) [plasma membrane] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GpIb-IX-V:Collagen type I fibril:vWF [plasma membrane] (Mus musculus)
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Response to elevated platelet cytosolic Ca2+ (Mus musculus)
Platelet degranulation (Mus musculus)
Exocytosis of platelet alpha granule contents (Mus musculus)
Platelet alpha granule contents [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Autophosphorylation of PTK2 at Y397 (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Autophosphorylation of SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Clustering of Integrin alphaIIb beta3 complexes (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Dephosphorylation of inactive SRC by PTPB1 (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)
Interaction of SOS with GRB2 bound to FADK1 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
GRB2:SOS:p-PTK2:Focal adhesion [plasma membrane] (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Recruitment of GRB2 to p-PTK2 (Mus musculus)
GRB2 bound to pPTK2 in Focal adhesion [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Interaction of integrin alphaIIb beta3 with Fibrinogen (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Phosphorylation of pPTK2 by SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Release of CSK from SRC (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:p(Y530)-SRC:CSK) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
SYK activation by SRC (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM:ECM ligands:2X(Integrin alphaIIb beta3:Active (p-Y419)-SRC):p(Y)-SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
SYK binds to integrin alphaIIb beta3 (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Translocation of PTK2 to Focal complexes (Mus musculus)
Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
p130Cas linkage to MAPK signaling for integrins (Mus musculus)
Crk binding to p130cas (Mus musculus)
CRK:p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Phosphorylation of BCAR1 by SRC-PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
p-BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Recruitment of BCAR1 to PTK2 complex (Mus musculus)
BCAR1:Talin:RIAM:ECM ligands:alphaIIb beta3:p-Y419 SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Talin:RIAM complex:ECM ligands: Integrin alphaIIb beta3:Active (p-Y419)-SRC:p-6Y-PTK2 [plasma membrane] (Mus musculus)
Talin:RIAM complex:ECM ligands:2X(Integrin alphaIIb beta3:Active p-Y419-SRC) [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
MAP2K and MAPK activation (Mus musculus)
Dissociation of RAS:RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Dual mechanism MAP2K inhibitors bind MAP2Ks (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Dual mechanism MAPK inhibitors bind MAPKs (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
MAP2Ks and MAPKs bind to the activated RAF complex (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
MAP2Ks phosphorylate MAPKs (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:dual mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
RAF phosphorylates MAP2K dimer (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex:dual mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Single mechanism MAP2K inhibitors bind phosphorylated MAP2Ks (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK:single mechanism MAP2K inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
Single mechanism MAPK inhibitors bind phosphorylated MAPK (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK:single mechanism MAPK inhibitors [plasma membrane] (Mus musculus)
activated RAF:scaffold:p-2S MAP2K:p-2T MAPK complex [plasma membrane] (Mus musculus)
RAF/MAPK scaffolds [cytosol] (Mus musculus)
Focal Adhesion/Focal contacts [plasma membrane] (Mus musculus)
Vinculin bound to alphaIIbbeta3 [plasma membrane] (Mus musculus)
Focal complex [plasma membrane] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
Vwf [extracellular region] (Mus musculus)
External Reference Information
External Reference
UniProt:Q8CIZ8
Gene Names
Vwf
Reference Genes
BioGPS Gene:22371 Vwf
ENSEMBL:ENSMUSG00000001930
KEGG Gene (Mus musculus):22371 Vwf
Monarch:22371 Vwf
NCBI Gene:22371 Vwf
Reference Transcript
RefSeq:NM_011708.4 Vwf
Participates
as a member of
Platelet alpha granule contents [extracellular region] (Mus musculus)
Integrin alphaIIb beta3 ECM ligands [extracellular region] (Mus musculus)
as an input of
vWF binds to collagen (Mus musculus)
as a component of
Collagen type I fibril:vWF [extracellular region] (Mus musculus)
Other forms of this molecule
Vwf [platelet alpha granule lumen]
Vwf [extracellular region]
Vwf [extracellular region]
Vwf [extracellular region]
Inferred From
VWF(23-763) [extracellular region]
(Homo sapiens)
Cross References
RefSeq
NP_035838.3
PRO
Q8CIZ8
MGI
98941
PDB
1U0O
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