Reactome | Ap2a2 [endolysosome membrane]

Ap2a2 [endolysosome membrane]

Stable Identifier

R-MMU-6784819

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

endolysosome membrane

Synonyms

AP2A2(1-939), P17427

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - MHC class II antigen presentation (Mus musculus)
    - Internalization of MHC II:Ii clathrin coated vesicle (Mus musculus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Mus musculus)
        
        Ap2a2 [endolysosome membrane] (Mus musculus)
    - Uncoating of clathrin-coated vesicles and fusion with endosomes (Mus musculus)
      - Clathrin coated MHC class II alpha/beta/Ii nonamer [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Mus musculus)
        
        Ap2a2 [endolysosome membrane] (Mus musculus)
      - Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Mus musculus)
        
        Ap2a2 [endolysosome membrane] (Mus musculus)

Transport of small molecules (Mus musculus)

- Plasma lipoprotein assembly, remodeling, and clearance (Mus musculus)
  - Plasma lipoprotein clearance (Mus musculus)
    - LDL clearance (Mus musculus)
      - Degradation of PCSK9:LDLR:Clathrin-coated vesicle (Mus musculus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Mus musculus)
        
        Ap2a2 [endolysosome membrane] (Mus musculus)
        
        PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Mus musculus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Mus musculus)
        
        Ap2a2 [endolysosome membrane] (Mus musculus)
      - PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome (Mus musculus)
        
        PCSK9:LDLR:Clathrin:AP2 [endolysosome membrane] (Mus musculus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Mus musculus)
        
        Ap2a2 [endolysosome membrane] (Mus musculus)
    - VLDLR internalisation and degradation (Mus musculus)
      - VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane (Mus musculus)
        
        VLDL:PCSK9:Clathrin:AP2 [lysosomal membrane] (Mus musculus)
        
        Clathrin:AP2 complex [clathrin-coated endocytic vesicle membrane] (Mus musculus)
        
        Adaptor protein 2 complex [endolysosome membrane] (Mus musculus)
        
        Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane] (Mus musculus)
        
        Ap2a2 [endolysosome membrane] (Mus musculus)

External Reference Information

External Reference

UniProt:P17427

Gene Names

Ap2a2

Reference Genes

BioGPS Gene:11772 Ap2a2

ENSEMBL:ENSMUSG00000002957

KEGG Gene (Mus musculus):11772 Ap2a2

Monarch:11772 Ap2a2

NCBI Gene:11772 Ap2a2

UCSC:P17427 Ap2a2

Reference Transcript

RefSeq:NM_007459.3 Ap2a2

Other Identifiers

100492_at

102835_at

10558971

11772

1435869_s_at

1452490_a_at

1455482_at

17484966

4358565

4374311

4432006

4598837

4669897

4676897

4710673

4781779

4895566

4949146

4963437

4997098

5015503

5086832

5133888

5142371

5155365

5163697

5201722

5243195

5247241

5294417

5303296

5352865

5360497

5416323

5456485

5464585

5472708

5491236

5498267

5574710

A_51_P312474

A_52_P354298

A_52_P668488

GE33426

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005886

GO:0005905

GO:0006810

GO:0006886

GO:0006897

GO:0006898

GO:0008021

GO:0008150

GO:0008289

GO:0015031

GO:0016020

GO:0016192

GO:0019899

GO:0019900

GO:0019901

GO:0019904

GO:0030117

GO:0030122

GO:0030131

GO:0030141

GO:0030154

GO:0031410

GO:0032991

GO:0035091

GO:0035615

GO:0043167

GO:0043226

GO:0044877

GO:0048856

GO:0072583

GO:0097718

GO:0140312

GO:1902036

ILMN_1237891

Msa.11835.0_s_at

aa000469_at

aa000469_g_at

mMC006867

x14972_s_at

Participant Of

hasMember

Adaptor protein complex 2 (AP-2) large adaptins [endolysosome membrane]

Other forms of this molecule

Ap2a2 [secretory granule membrane]

Ap2a2 [ficolin-1-rich granule membrane]

Ap2a2 [endocytic vesicle membrane]

Ap2a2 [plasma membrane]

Ap2a2 [clathrin-coated endocytic vesicle membrane]

Ap2a2 [cytosol]

Inferred From

AP2A2(1-939) [endolysosome membrane] (Homo sapiens)

Cross References

RefSeq

NP_031485.3

Ensembl

ENSMUST00000003038, ENSMUSP00000003038, ENSMUSG00000002957

PRO

P17427

MGI

101920

PDB

1KY7, 1B9K, 1QTS, 2JKT, 6OWO, 1KYF, 1QTP, 6OXL, 3HS8, 2JKR, 1KYD, 2VJ0, 1KY6, 1W80, 1KYU

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O88339	2	Epn1 [plasma membrane] (R-RNO-182952) Epn1 [cytosol] (R-RNO-8865826)	0.743	4
UniProt:P42567	2	Eps15 [cytosol] (R-MMU-182920) phospho-Eps15 [cytosol] (R-MMU-8867028)	0.676	3

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