Reactome | Hspa1b [nucleoplasm]

Hspa1b [nucleoplasm]

Stable Identifier

R-MMU-6792605

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

HSPA1A, P17879

Locations in the PathwayBrowser

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Cellular responses to external stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to heat stress (Mus musculus)
    - HSF1-dependent transactivation (Mus musculus)
      - Attenuation phase (Mus musculus)
        
        HSF1 acetylation at Lys80 (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 binds HSF1 (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
      - HSF1-mediated gene expression (Mus musculus)
        
        Heat shock inducible proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
    - Regulation of HSF1-mediated heat shock response (Mus musculus)
      - HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm (Mus musculus)
        
        HSP70s:ADP [nucleoplasm] (Mus musculus)
        
        HSPA1A:ADP [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSPA1A:ATP [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
      - NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm (Mus musculus)
        
        Hikeshi:HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSP70s:ATP [nucleoplasm] (Mus musculus)
        
        HSPA1A:ATP [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
      - SIRT1 binds to HSF1 (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
      - SIRT1 deacetylates HSF1 (Mus musculus)
        
        HSP70:DNAJB1:HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)
        
        SIRT1:HSP70:DNAJB1:Ac-K80-HSF1:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1:Ac-K80-HSF1 trimer:target gene [nucleoplasm] (Mus musculus)
        
        HSP70:DNAJB1 [nucleoplasm] (Mus musculus)
        
        HSPA (HSP70) proteins [nucleoplasm] (Mus musculus)
        
        Homologues of HSPA1A [nucleoplasm] (Mus musculus)
        
        Hspa1b [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P17879

Gene Names

Hspa1b

Reference Genes

BioGPS Gene:15511 Hspa1b

ENSEMBL:ENSMUSG00000090877

ENSEMBL:ENSMUSG00000090877 Hspa1b

KEGG Gene (Mus musculus):15511 Hspa1b

Monarch:15511 Hspa1b

NCBI Gene:15511 Hspa1b

UCSC:P17879 Hspa1b

Reference Transcript

RefSeq:NM_010478.2 Hspa1b

Other Identifiers

100946_at

10450367

1427126_at

1427127_x_at

1452318_a_at

15511

17344126

5337357

A_52_P304902

A_52_P52803

A_55_P2068459

GO:0000003

GO:0000166

GO:0000278

GO:0002199

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005759

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006457

GO:0006810

GO:0006950

GO:0006986

GO:0007010

GO:0007049

GO:0007339

GO:0008150

GO:0008180

GO:0008219

GO:0009056

GO:0009408

GO:0016192

GO:0016887

GO:0019899

GO:0022607

GO:0031072

GO:0031625

GO:0032436

GO:0032991

GO:0034620

GO:0042026

GO:0043066

GO:0043154

GO:0043167

GO:0043226

GO:0044183

GO:0044297

GO:0051082

GO:0051085

GO:0051787

GO:0065003

GO:0090063

GO:0140014

GO:1901673

ILMN_2498263

ILMN_2530672

mMC015201

Participant Of

hasMember

Homologues of HSPA1A [nucleoplasm]

Other forms of this molecule

Hspa1b [cytosol]

Hspa1b [extracellular region]

Hspa1b [ficolin-1-rich granule lumen]

Inferred From

HSPA1A [nucleoplasm] (Homo sapiens)

HSPA1B [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_034608.2

Ensembl

ENSMUSG00000090877, ENSMUSP00000133815, ENSMUST00000172753

PRO

P17879

MGI

99517

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35438 Grin1	3	Grin1 [endoplasmic reticulum membrane] (R-MMU-9610359) Grin1 [plasma membrane] (R-MMU-3928395) Grin1 [transport vesicle membrane] (R-MMU-9610566)	0.643	5
UniProt:Q01097 Grin2b	7	phospho-Grin2b [plasma membrane] (R-MMU-3928477) p-Nr2b [plasma membrane] (R-MMU-3928470) Grin2b [endoplasmic reticulum membrane] (R-MMU-9610361) Grin2b [plasma membrane] (R-MMU-3928478) Grin2b [transport vesicle membrane] (R-MMU-9610571) Grin2b [endoplasmic reticulum membrane] (R-MMU-9609765) Grin2b [plasma membrane] (R-MMU-419558)	0.527	3
UniProt:P70196 Traf6	9	Traf6 [cytosol] (R-MMU-6782845) Traf6 [cytosol] (R-MMU-6783233) Traf6 [cytosol] (R-MMU-933459) Traf6 [endosome membrane] (R-MMU-450272) Traf6 [plasma membrane] (R-MMU-936955) Traf6 [endosome membrane] (R-MMU-450227) Traf6 [plasma membrane] (R-MMU-936980) Traf6 [cytosol] (R-MMU-2685681) Traf6 [cytosol] (R-MMU-166366)	0.524	3

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