Mt2 binds zinc

Stable Identifier
R-MMU-6798563
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
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Mt2 binds zinc

Mouse Mt2 binds 7 atoms of divalent zinc. The mMt2 isoform exhibits metal ion binding abilities distinct from those of mMt1, with a clear preference for Zn(II) coordination, if compared to Cu(I) or even to Cd(II). This is in full agreement with the gene expression regulation pattern for the Mt1 and Mt2 genes, as well as with the hypothesized preferential role of mMt2 in Zn(II) homeostasis mechanisms, while Mt1, possibly differentiated from a most recent duplication event in the mammalian metallothionein gene cluster, would have evolved to detoxify Cd(II), and probably other divalent metal ions (Artells et al, 2013).

Literature References
PubMed ID Title Journal Year
23925449 Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities

Artells, E, Palacios, Ò, Capdevila, M, Atrian, S

Metallomics 2013
Participants
Orthologous Events
Authored
Reviewed
Created