Mt1 binds cadmium

Stable Identifier
R-MMU-6798570
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
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Mt1 binds cadmium

Mouse Mt1 binds 7 atoms of divalent cadmium (Zangger et al. 1999, Tio et al. 2004, Artells et al. 2013). The mMt1 isoform exhibits metal ion binding abilities distinct from those of mMt2, with mMt2 showing a clear preference for Zn(II) coordination, if compared to Cu(I) or even to Cd(II). This is in full agreement with the gene expression regulation pattern for the Mt1 and Mt2 genes, as well as with the hypothesized preferential role of mMt2 in Zn(II) homeostasis mechanisms, while Mt1, possibly differentiated from a most recent duplication event in the mammalian metallothionein gene cluster, would have evolved to detoxify Cd(II), and probably other divalent metal ions (Artells et al, 2013).

Literature References
PubMed ID Title Journal Year
15033980 Functional differentiation in the mammalian metallothionein gene family: metal binding features of mouse MT4 and comparison with its paralog MT1

Tío, L, Villarreal, L, Atrian, S, Capdevila, M

J. Biol. Chem. 2004
10631978 Three-dimensional solution structure of mouse [Cd7]-metallothionein-1 by homonuclear and heteronuclear NMR spectroscopy

Zangger, K, Oz, G, Otvos, JD, Armitage, IM

Protein Sci. 1999
23925449 Mammalian MT1 and MT2 metallothioneins differ in their metal binding abilities

Artells, E, Palacios, Ò, Capdevila, M, Atrian, S

Metallomics 2013
Participants
Orthologous Events
Authored
Reviewed
Created