Nr2e1 represses Pten transcription

Stable Identifier
R-MMU-6807098
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Nr2e1 represses Pten transcription

Mouse Nr2e1 (Tlx) binds the evolutionarily conserved Tlx site in the mouse Pten promoter and represses Pten transcription. Formation of a complex between Nr2e1 and Atn1 (Atrophin-1) is needed for Nr2e1-mediated transcriptional repression (Zhang et al. 2006).

Literature References
PubMed ID Title Journal Year
16702404 Nuclear receptor TLX prevents retinal dystrophy and recruits the corepressor atrophin1

Zhang, CL, Zou, Y, Yu, RT, Gage, FH, Evans, RM

Genes Dev. 2006
Participants
This event is regulated
Orthologous Events
Authored
Reviewed
Created