Reactome | Ints2 [nucleoplasm]

Ints2 [nucleoplasm]

Stable Identifier

R-MMU-6807448

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

INTS2, Q80UK8

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        Integrator [nucleoplasm] (Mus musculus)
        
        Ints2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q80UK8

Gene Names

Ints2

Reference Genes

BioGPS Gene:70422 Ints2

ENSEMBL:ENSMUSG00000018068

ENSEMBL:ENSMUSG00000018068.14 Ints2

KEGG Gene (Mus musculus):70422 Ints2

Monarch:70422 Ints2

NCBI Gene:70422 Ints2

UCSC:Q80UK8 Ints2

Reference Transcript

Other Identifiers

10389421

106527_at

114996_at

1429461_at

1436247_at

17267237

4312565

4314523

4332383

4338313

4349733

4377091

4414201

4499945

4504704

4522854

4586626

4642375

4690296

4774055

4826764

4834292

4900085

4908336

4998542

5038172

5057843

5073292

5114956

5186287

5362176

5365407

5410193

5432414

5433271

5479987

5520804

5581561

70422

98227_at

A_51_P413097

A_55_P2254276

GE39718

GO:0003674

GO:0005634

GO:0005635

GO:0005737

GO:0016020

GO:0016073

GO:0016180

GO:0031965

GO:0032039

GO:0034472

GO:0043226

ILMN_2657510

mMC003980

Participates

as a component of

Integrator [nucleoplasm] (Mus musculus)

Inferred From

INTS2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_081697.2, XP_006534243.1, XP_006534242.1, XP_006534244.1, XP_006534245.1

Ensembl

ENSMUST00000108039, ENSMUSP00000018212, ENSMUSP00000103674, ENSMUSG00000018068, ENSMUST00000018212

PRO

Q80UK8

MGI

1917672