PI(3,5)P2 is dephosphorylated to PI5P by the Mtmr2:Sbf2 tetramer at the plasma membrane

Stable Identifier
R-MMU-6809945
Type
Reaction
Species
Mus musculus
Compartment
plasma membrane, cytosol
General
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PI(3,5)P2 is dephosphorylated to PI5P by the Mtmr2:Sbf2 tetramer at the plasma membrane

Formation of the complex with Sbf2 (Mtmr13) dramatically increases phosphatidylinositol-(3,5)-bisphosphate 3-phosphatase catalytic activity of mouse Mtmr2 (Berger et al. 2006).

Literature References
PubMed ID Title Journal Year
16399794 Multi-level regulation of myotubularin-related protein-2 phosphatase activity by myotubularin-related protein-13/set-binding factor-2

Berger, P, Berger, I, Schaffitzel, C, Tersar, K, Volkmer, B, Suter, U

Hum. Mol. Genet. 2006
Participants
Input
Output
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity of Mtmr2:Sbf2 Tetramer [cytosol]
Physical Entity
Mtmr2:Sbf2 Tetramer [cytosol]
Activity
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity (0052629)
Orthologous Events
PI(3,5)P2 is dephosphorylated to PI5P by the MTMR2:SBF2 tetramer at the plasma membrane (Homo sapiens)
Authored
Orlic-Milacic, M  (2015-11-13)
Reviewed
Rush, MG  (2017-01-10)
Created
Orlic-Milacic, M  (2015-11-13)
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