Hoxa2 chromatin is activated

Stable Identifier
R-MMU-6810138
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Summation

As inferred from mouse embryonic stem cells activated by retinoic acid (Kashyap et al. 2011, Mazzoni et al. 2013, Shpargel et al. 2014) and human cell lines, activation of Hoxa2 chromatin is accompanied by loss of methylation at lysine-27 of histone H3 (H3K27, Kashyap et al. 2011, Mazzoni et al. 2013, Shpargel et al. 2014), dissociation of polycomb repressive complexes (Mazzoni et al. 2013), and gain of methylation at H3K4 (Kashyap et al. 2011). The histone demethylase Kdm6a and possibly other factors (Shpargel et al. 2014) may participate in removing H3K27 methylation. The Mll2 complex methylates H3K4 at Hoxa2 in fibroblasts (Wang et al. 2009).

Literature References
PubMed ID Title Journal Year
21087926 Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid

Kashyap, V, Gudas, LJ, Brenet, F, Funk, P, Viale, A, Scandura, JM

J. Biol. Chem. 2011
19703992 Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II

Wang, P, Lin, C, Smith, ER, Guo, H, Sanderson, BW, Wu, M, Gogol, M, Alexander, T, Seidel, C, Wiedemann, LM, Ge, K, Krumlauf, R, Shilatifard, A

Mol. Cell. Biol. 2009
25101834 KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development

Shpargel, KB, Starmer, J, Yee, D, Pohlers, M, Magnuson, T

PLoS Genet. 2014
23955559 Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

Mazzoni, EO, Mahony, S, Peljto, M, Patel, T, Thornton, SR, McCuine, S, Reeder, C, Boyer, LA, Young, RA, Gifford, DK, Wichterle, H

Nat. Neurosci. 2013
Participants
Orthologous Events
Authored
Reviewed