Hoxb3 chromatin is activated

Stable Identifier
R-MMU-6810150
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
Summation

As inferred from mouse embryonic stem cells activated by retinoic acid (Kashyap et al. 2011, Mazzoni et al. 2013) and human cells, activation of chromatin at Hoxb3 is accompanied by loss of methylation at lysine-27 of histone H3 (H3K27me3, Kashyap et al. 2011, Mazzoni et al. 2013), loss of PRC2 (Mazzoni et al. 2013), and gain of methylation at H3K4 (Kashyap et al. 2011). The Mll2 complex methylates H3K4 at Hoxb3 in fibroblasts (Wang et al. 2009). In human cells the demethylase KDM6A (UTX) binds HOXB3 chromatin during activation and participates in demethylating H3K27me3.

Literature References
PubMed ID Title Journal Year
21087926 Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid

Kashyap, V, Gudas, LJ, Brenet, F, Funk, P, Viale, A, Scandura, JM

J. Biol. Chem. 2011
19703992 Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II

Wang, P, Lin, C, Smith, ER, Guo, H, Sanderson, BW, Wu, M, Gogol, M, Alexander, T, Seidel, C, Wiedemann, LM, Ge, K, Krumlauf, R, Shilatifard, A

Mol. Cell. Biol. 2009
9144291 Segmental regulation of Hoxb-3 by kreisler

Manzanares, M, Cordes, S, Kwan, CT, Sham, MH, Barsh, GS, Krumlauf, R

Nature 1997
23955559 Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

Mazzoni, EO, Mahony, S, Peljto, M, Patel, T, Thornton, SR, McCuine, S, Reeder, C, Boyer, LA, Young, RA, Gifford, DK, Wichterle, H

Nat. Neurosci. 2013
Participants
Orthologous Events
Authored
Reviewed