Hoxa3 chromatin is activated

Stable Identifier
R-MMU-6810169
Type
Reaction [omitted]
Species
Mus musculus
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General
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Hoxa3 chromatin is activated

As inferred from mouse embryonic stem cells (Kashyap et al. 2011, Mazzoni et al. 2013) and embryos (Diman et al. 2011) activated by retinoic acid and human fibroblasts and embryonal carcinoma cells, Hoxa3 chromatin is activated by loss of methylation at lysine-27 of histone H3 (H3K27me3, Kashyap et al. 2011, Mazzoni et al. 2013). loss of Polycomb repressive complex (PRC2, Mazzoni et al. 2013), and gain of H3K4me3 (Kashyap et al. 2011). The Mll2 complex methylates H3K4 at Hoxa3 in fibroblasts (Wang et al. 2009). In human cells KDM6A (UTX) binds HOXA3 and participates in the loss of H3K27me3.

Literature References
PubMed ID Title Journal Year
21087926 Epigenomic reorganization of the clustered Hox genes in embryonic stem cells induced by retinoic acid

Kashyap, V, Gudas, LJ, Brenet, F, Funk, P, Viale, A, Scandura, JM

J. Biol. Chem. 2011
19703992 Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II

Wang, P, Lin, C, Smith, ER, Guo, H, Sanderson, BW, Wu, M, Gogol, M, Alexander, T, Seidel, C, Wiedemann, LM, Ge, K, Krumlauf, R, Shilatifard, A

Mol. Cell. Biol. 2009
25101834 KDM6 demethylase independent loss of histone H3 lysine 27 trimethylation during early embryonic development

Shpargel, KB, Starmer, J, Yee, D, Pohlers, M, Magnuson, T

PLoS Genet. 2014
22110697 A retinoic acid responsive Hoxa3 transgene expressed in embryonic pharyngeal endoderm, cardiac neural crest and a subdomain of the second heart field

Diman, NY, Remacle, S, Bertrand, N, Picard, JJ, Zaffran, S, Rezsohazy, R

PLoS ONE 2011
23955559 Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

Mazzoni, EO, Mahony, S, Peljto, M, Patel, T, Thornton, SR, McCuine, S, Reeder, C, Boyer, LA, Young, RA, Gifford, DK, Wichterle, H

Nat. Neurosci. 2013
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