Reactome | RPAP2 [nucleoplasm]

RPAP2 [nucleoplasm]

Stable Identifier

R-MMU-6810227

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

Q8VC34

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser2,7 CTD):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RDRP1A,B:RDRP2:RPAP2:Integrator:LEC [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)
      - RPAP2 [nucleoplasm] (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        RNA polymerase II (phospho-Ser5,7 CTD):RPRD1A,B:RPRD2:RPAP2 [nucleoplasm] (Mus musculus)
        
        RPAP2 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8VC34

Reference Genes

BioGPS Gene:231571

ENSEMBL:ENSMUSG00000033773

ENSEMBL:ENSMUSG00000033773.15

KEGG Gene (Mus musculus):231571

Monarch:231571

NCBI Gene:231571

UCSC:Q8VC34

Reference Transcript

Other Identifiers

10523880

1424559_at

1435034_at

163417_at

163601_at

17440086

231571

4335176

4456370

4459916

4495914

4573180

4576071

4629016

4669527

4681208

4757166

4856336

4884491

4917207

5019086

5141000

5161756

5202282

5283606

5439167

5445623

5470307

5504007

5552400

5555307

5564339

A_51_P378558

A_55_P2184905

A_65_P03606

GE130393

GO:0003824

GO:0004721

GO:0004722

GO:0005634

GO:0005730

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0008420

GO:0009301

GO:0016073

GO:0016787

GO:0017018

GO:0023052

GO:0036499

GO:0043175

GO:0043226

GO:0046872

GO:0097550

GO:0140096

ILMN_1237312

ILMN_2609494

ILMN_2652260

ILMN_2748616

ILMN_2977210

ILMN_2977212

mMC022756

mMC023332

mMR027214

Participates

as a component of

as an input of

RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)

Inferred From

RPAP2 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_001276499.1, NP_001156934.1, NP_659160.2, NP_001276498.1, NP_001156933.1, XP_006534963.1

Ensembl

ENSMUST00000112655, ENSMUST00000065422, ENSMUSP00000108270, ENSMUST00000112650, ENSMUST00000112651, ENSMUSG00000033773, ENSMUST00000112654, ENSMUSP00000108273, ENSMUSP00000070209, ENSMUSP00000108274, ENSMUSP00000108269

PRO

Q8VC34

MGI

2141142