Reactome | Rpl3l [cytosol]

Rpl3l [cytosol]

Stable Identifier

R-MMU-72450

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

RPL3L, E9PWZ3

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        RPL3,RPL3L [cytosol] (Mus musculus)
        
        Rpl3l [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:E9PWZ3

Gene Names

Rpl3l

Reference Genes

BioGPS Gene:66211 Rpl3l

ENSEMBL:ENSMUSG00000002500

ENSEMBL:ENSMUSG00000002500.16 Rpl3l

KEGG Gene (Mus musculus):66211 Rpl3l

Monarch:66211 Rpl3l

NCBI Gene:66211 Rpl3l

UCSC:E9PWZ3 Rpl3l

Reference Transcript

Other Identifiers

10442584

1449398_at

165907_f_at

167244_f_at

17334406

4681498

4888500

4972394

5010576

5113438

5165704

5228157

5360006

5499287

5530699

66211

A_51_P243123

GE40742

GO:0003723

GO:0003735

GO:0005198

GO:0005829

GO:0005840

GO:0006412

GO:0010832

GO:0016202

GO:0022625

GO:0030154

GO:0043226

GO:0048856

GO:1990904

ILMN_2649810

mMC004378

Participates

as a candidate of

RPL3,RPL3L [cytosol] (Mus musculus)

Inferred From

RPL3L [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_079701.1, NP_001157417.1

Ensembl

ENSMUSP00000129325, ENSMUST00000170239, ENSMUSG00000002500

MGI

1913461

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