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Shc1 [cytosol]
Stable Identifier
R-MMU-74680
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
SHC1, P98083
Locations in the PathwayBrowser
Expand all
Developmental Biology (Mus musculus)
Nervous system development (Mus musculus)
Axon guidance (Mus musculus)
RET signaling (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 in the RET complex is phosphorylated (Mus musculus)
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Hemostasis (Mus musculus)
Cell surface interactions at the vascular wall (Mus musculus)
Tie2 Signaling (Mus musculus)
Interaction of Tie2 and Shc1 (Mus musculus)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Platelet activation, signaling and aggregation (Mus musculus)
Platelet Aggregation (Plug Formation) (Mus musculus)
Integrin signaling (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Immune System (Mus musculus)
Cytokine Signaling in Immune system (Mus musculus)
Signaling by Interleukins (Mus musculus)
Interleukin-2 family signaling (Mus musculus)
Interleukin-2 signaling (Mus musculus)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 bound to IL2 receptor is phosphorylated (Mus musculus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Mus musculus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2, p(Y593,628)-Bc:SHC1 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signal Transduction (Mus musculus)
Integrin signaling (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 bound to integrin alphaIIb beta3 is phosphorylated somehow (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by Nuclear Receptors (Mus musculus)
ESR-mediated signaling (Mus musculus)
Extra-nuclear estrogen signaling (Mus musculus)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
MMPs cleave HB-EGF (Mus musculus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by EGFR (Mus musculus)
SHC1 events in EGFR signaling (Mus musculus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by ERBB2 (Mus musculus)
SHC1 events in ERBB2 signaling (Mus musculus)
SHC1 phosphorylation by ERBB2 heterodimers (Mus musculus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by ERBB4 (Mus musculus)
SHC1 events in ERBB4 signaling (Mus musculus)
Phosphorylation of SHC1 by ERBB4 homodimers (Mus musculus)
SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
SHC1 binds P-ERBB4 isoform dimers (Mus musculus)
SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
Binding of SHC1 to insulin receptor (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
Phosphorylation of SHC1 (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
Shc1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P98083 Shc1
Gene Names
Shc1, Shc, ShcA
Chain
chain:1-579
Reference Genes
BioGPS Gene:20416 Shc1
ENSEMBL:ENSMUSG00000042626 Shc1
KEGG Gene (Mus musculus):20416 Shc1
Monarch:20416 Shc1
NCBI Gene:20416 Shc1
UCSC:P98083 Shc1
Reference Transcript
RefSeq:NM_011368.5 Shc1
RefSeq:NM_001113331.2 Shc1
Other Identifiers
104350_at
10493519
10493530
1422853_at
1422854_at
17399432
17399451
20416
4438479
4464752
4597304
4598666
4611903
4781818
4827703
4831049
4843718
4861442
4866348
4978968
5006563
5040489
5077328
5114887
5151032
5151355
5162067
5230211
5234716
5239308
5244996
5279142
5294395
5334342
5347788
5365949
5475784
5525559
5561997
5567359
93713_at
A_52_P384250
A_55_P1979082
GE41902
GO:0001525
GO:0003674
GO:0007165
GO:0008150
GO:0019899
GO:0030971
GO:0035556
GO:0048646
GO:0048856
ILMN_1236765
ILMN_2637676
ILMN_2716426
ILMN_2957070
Msa.1387.0_s_at
aa119070_s_at
mMC021453
mMC025703
mMR029196
Participates
as an input of
2x p-5Y-RET:GDNF:GFRA complexes bind SHC1 (Mus musculus)
Activated integrin alphaIIb beta3 binds SHC1 (Mus musculus)
Binding of SHC1 to insulin receptor (Mus musculus)
Estrogen receptor binds IGF1R and SHC1 in response to estrogen (Mus musculus)
Interaction of Tie2 and Shc1 (Mus musculus)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Mus musculus)
Recruitment of SHC1 is mediated by Y593 of the common beta chain (Mus musculus)
SHC1 binds P-ERBB4 isoform dimers (Mus musculus)
SHC1 binds to the phosphorylated EGF receptor:ligand complex (Mus musculus)
as a component of
2x p-5Y-RET:GDNF:GFRA complexes:SHC1 [plasma membrane] (Mus musculus)
ANGPT1:p-5Y,S119-TEK:SHC1 [plasma membrane] (Mus musculus)
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Mus musculus)
ESTG:ESR1:p-3Y-IGF1R:SHC1 [plasma membrane] (Mus musculus)
High affinity GM-CSF receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
High affinity IL-5 receptor complex dimer, inactive JAK2, phosphorylated Bc:SHC1 [plasma membrane] (Mus musculus)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Mus musculus)
Insulin:p-6Y-Insulin receptor:SHC1 [plasma membrane] (Mus musculus)
Integrin alphaIIb beta 3:p(Y530)-SRC:CSK:Talin:RIAM complex:SHC [plasma membrane] (Mus musculus)
SHC1:p-ERBB4 [plasma membrane] (Mus musculus)
SHC1:Phosphorylated ERBB2 heterodimers [plasma membrane] (Mus musculus)
Other forms of this molecule
Shc1 [plasma membrane]
Shc1 [plasma membrane]
Shc1 [plasma membrane]
p-Y-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
Shc1 [cytosol]
phospho-Shc1 [plasma membrane]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [plasma membrane]
Shc1 [cytosol]
phospho-Shc1 [cytosol]
phospho-Shc1 [cytosol]
Inferred From
SHC1-1 [cytosol]
(Homo sapiens)
SHC1 [cytosol]
(Homo sapiens)
SHC1 [cytosol]
(Homo sapiens)
Cross References
RefSeq
NP_035498.2
,
NP_001106802.1
Target Pathogen
5b354852be737e166372ec2d
Ensembl
ENSMUST00000107417
,
ENSMUSP00000103040
,
ENSMUSP00000035361
,
ENSMUST00000039110
,
ENSMUSP00000140336
,
ENSMUST00000191485
,
ENSMUSP00000091940
,
ENSMUST00000094378
,
ENSMUSG00000042626
PRO
P98083
MGI
98296
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q60631 Grb2
3
Grb2 [plasma membrane]
(R-MMU-202993)
Grb2 [cytosol]
(R-MMU-74686)
Grb2 [cytosol]
(R-MMU-443287)
0.899
8
UniProt:Q9JKF1
3
Iqgap1 [secretory granule membrane]
(R-MMU-6804803)
Iqgap1 [plasma membrane]
(R-MMU-381681)
Iqgap1 [cytosol]
(R-MMU-5626371)
0.65
5
UniProt:P35831
1
Ptpn12 [cytosol]
(R-MMU-432933)
0.558
2
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