Reactome | Grb2 [cytosol]

Grb2 [cytosol]

Stable Identifier

R-MMU-74686

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

GRB2-1, Q60631

Locations in the PathwayBrowser for interactor UniProt:P18052"

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External Reference Information

External Reference

UniProt:Q60631 Grb2

Gene Names

Grb2

Chain

chain:1-217

Reference Genes

BioGPS Gene:14784 Grb2

ENSEMBL:ENSMUSG00000059923 Grb2

KEGG Gene (Mus musculus):14784 Grb2

Monarch:14784 Grb2

NCBI Gene:14784 Grb2

UCSC:Q60631 Grb2

Reference Transcript

Other Identifiers

101034_at

10392990

1418508_a_at

1449111_a_at

14784

17272004

4311802

4387111

4420339

4425001

4599844

4621585

4780811

4814468

4983599

5066515

5109277

5119057

5148685

5153093

5236475

5312349

5312784

5463859

5553561

A_55_P2123727

GE34513

GO:0000003

GO:0001784

GO:0003674

GO:0005070

GO:0005154

GO:0005168

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005768

GO:0005794

GO:0005829

GO:0005886

GO:0005911

GO:0006464

GO:0006810

GO:0006950

GO:0007010

GO:0007165

GO:0007173

GO:0007265

GO:0007568

GO:0008150

GO:0008180

GO:0008286

GO:0009790

GO:0012506

GO:0016020

GO:0016192

GO:0017124

GO:0019899

GO:0019901

GO:0019903

GO:0019904

GO:0022607

GO:0030154

GO:0030674

GO:0030838

GO:0031410

GO:0031532

GO:0031623

GO:0032991

GO:0042770

GO:0042802

GO:0043226

GO:0043408

GO:0043560

GO:0044877

GO:0046875

GO:0048646

GO:0048856

GO:0051219

GO:0060670

GO:0065003

GO:0070436

GO:0071479

GO:2000379

ILMN_1222450

ILMN_2995537

mMC014789

u07617_s_at

Participant Of

hasComponent

input

output

PPTN11 dephosphorylates SPRY2

hasMember

SH3 domain proteins [cytosol]

Other forms of this molecule

Grb2 [plasma membrane]

Grb2 [cytosol]

Inferred From

GRB2 [cytosol] (Homo sapiens)

GRB2-1 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001300865.1, NP_001300866.1, NP_032189.1

ZINC target

Q60631

Ensembl

ENSMUSP00000021090, ENSMUST00000106497, ENSMUST00000106499, ENSMUST00000021090, ENSMUSP00000102108, ENSMUSG00000059923, ENSMUSP00000102106

PRO

Q60631

MGI

95805

ZINC - Predictions - Purchasable

GRB2_MOUSE

PDB

3GBQ, 2GBQ, 1GBR, 1GBQ, 4GBQ

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98083 Shc1	2	Shc1 [cytosol] (R-MMU-1248757) p-Y-Shc1 [cytosol] (R-MMU-8983175)	0.899	8
UniProt:Q9QYY0 Gab1	5	Gab1 [cytosol] (R-MMU-9031464) phospho-Gab1 [cytosol] (R-MMU-8855306) phospho-Gab1 [cytosol] (R-MMU-180496) phospho-Gab1 [cytosol] (R-MMU-180344) Gab1 [cytosol] (R-MMU-179795)	0.791	9
UniProt:Q62245 Sos1	4	Sos1 [cytosol] (R-MMU-443318) phospho-Sos1 [cytosol] (R-MMU-109821) Sos1 [plasma membrane] (R-MMU-983559) Sos1 [cytosol] (R-MMU-64847)	0.757	7
UniProt:Q02384	1	Sos2 [cytosol] (R-MMU-167221)	0.678	5
UniProt:O54957	4	phospho-Lat [plasma membrane] (R-MMU-2396597) phospho-Lat [plasma membrane] (R-MMU-434829) Lat [plasma membrane] (R-MMU-202322) phospho-Lat [plasma membrane] (R-MMU-202364)	0.669	5
UniProt:P18052	1	Ptpra [plasma membrane] (R-MMU-388755)	0.656	4
UniProt:P22682	6	phospho-Cbl [cytosol] (R-MMU-8875457) phospho-Cbl [plasma membrane] (R-MMU-182923) phospho-Cbl [cytosol] (R-MMU-182940) phospho-Cbl [cytosol] (R-MMU-8848826) phospho-Cbl [cytosol] (R-MMU-912656) Cbl [cytosol] (R-MMU-112199)	0.643	7
UniProt:P35329	3	Cd22 [plasma membrane] (R-MMU-197703) Cd22 [plasma membrane] (R-MMU-5690736) phospho-Cd22 [plasma membrane] (R-MMU-5690726)	0.623	4
UniProt:P04925 Prnp	2	Prnp [cytosol] (R-MMU-9617597) Major prion protein [plasma membrane] (R-MMU-420340)	0.618	7
UniProt:Q61234 SNTA1			0.618	3
UniProt:P35235 Ptpn11	5	Ptpn11 [cytosol] (R-MMU-210002) p-Y546,Y584-Shp2 [cytosol] (R-MMU-443116) Ptpn11 [nucleoplasm] (R-MMU-8937745) Ptpn11 [cytosol] (R-MMU-162563) phospho-Ptpn11 [cytosol] (R-MMU-162573)	0.59	3
UniProt:P98078	3	Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [cytosol] (R-MMU-8862456) Dab2 [plasma membrane] (R-MMU-2980808)	0.576	4
UniProt:Q60749	3	phospho-Khdrbs1 [cytosol] (R-MMU-8848995) Khdrbs1 [nucleoplasm] (R-MMU-8848941) phospho-Khdrbs1 [nucleoplasm] (R-MMU-8848970)	0.573	2
UniProt:Q61824 Adam12	2	Adam12 [plasma membrane] (R-MMU-179792) ADAM 12 metalloprotease [plasma membrane] (R-MMU-179841)	0.571	3
UniProt:Q62077 Plcg1	10	Plcg1 [cytosol] (R-MMU-9638030) p-Y-Plcg1 [cytosol] (R-MMU-9029083) p-4Y-Plcg1 [plasma membrane] (R-MMU-9030452) P-Plcg1 [cytosol] (R-MMU-1251936) Plcg1 [plasma membrane] (R-MMU-1251925) phospho-Plcg1 [plasma membrane] (R-MMU-1169084) Plcg1 [plasma membrane] (R-MMU-167682) Plcg1 [cytosol] (R-MMU-202320) phospho-Plcg1 [cytosol] (R-MMU-202357) phospho-Plcg1 [plasma membrane] (R-MMU-167679)	0.564	2
UniProt:Q02858 Tek	4	Tie2 [plasma membrane] (R-MMU-211118) Phosphorylated_Tie2 [plasma membrane] (R-MMU-211116) Tek [plasma membrane] (R-MMU-197755) phospho-Tek [plasma membrane] (R-MMU-204772)	0.548	3
UniProt:Q3TTA7	1	Cblb [cytosol] (R-MMU-976009)	0.527	6
UniProt:Q8C180 Frs2	6	Frs2 [cytosol] (R-MMU-443125) p-Y-Frs2 [cytosol] (R-MMU-9031970) phospho-Frs2 [cytosol] (R-MMU-190355) phospho-Frs2 [plasma membrane] (R-MMU-1270462) Frs2 [plasma membrane] (R-MMU-170963) phospho-Frs2 [plasma membrane] (R-MMU-170959)	0.527	5
UniProt:P34152 Ptk2	13	phospho-Ptk2 [cytosol] (R-MMU-8874613) phospho-Ptk2 [cytosol] (R-MMU-9632393) phospho-Ptk2 [cytosol] (R-MMU-354128) phospho-Ptk2 [cytosol] (R-MMU-354068) Ptk2 [cytosol] (R-MMU-201621) phospho-Ptk2 [cytosol] (R-MMU-5218694) phospho-Ptk2 [cytosol] (R-MMU-5229006) phospho-Ptk2 [cytosol] (R-MMU-5218711) Fak1 [cytosol] (R-MMU-3928448) p-Y428-FAK1 [cytosol] (R-MMU-3928397) Ptk2 [cytosol] (R-MMU-202827) Ptk2 [cytosol] (R-MMU-202829) phospho-Ptk2 [cytosol] (R-MMU-8874600)	0.508	2
UniProt:Q52KG5	1	Kif26a [cytosol] (R-MMU-984675)	0.508	2
UniProt:Q3U1F9	2	phospho-Pag1 [plasma membrane] (R-MMU-180494) Pag1 [plasma membrane] (R-MMU-180500)	0.499	5
UniProt:Q9DD03 Rab13	4	Rab13 [cell junction] (R-MMU-8876591) GGC-Rab13 [cytoplasmic vesicle membrane] (R-MMU-1445096) Rab13 [cytosol] (R-MMU-8873767) Rab13 [cytosol] (R-MMU-8873674)	0.463	2

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