Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
phospho-Irs1 [cytosol]
Stable Identifier
R-MMU-74772
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-Y-IRS1, P35569
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by ALK (Mus musculus)
Active ALK phosphorylates IRS1 (Mus musculus)
Active ALK:pY-IRS1 [plasma membrane] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS activation (Mus musculus)
Dissociation of IRS-P from insulin receptor (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Phosphorylation of IRS (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Signal attenuation (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Signaling by LTK (Mus musculus)
Active LTK phosphorylates IRS1 (Mus musculus)
Active LTK:p-Y IRS1 [plasma membrane] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
IRS1 recruits GRB2 to active LTK (Mus musculus)
Active LTK:p-Y IRS1 [plasma membrane] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
PI3K/AKT activation (Mus musculus)
Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs1 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P35569 Irs1
Gene Names
Irs1, Irs-1
Chain
chain:1-1233
Reference Genes
BioGPS Gene:16367 Irs1
KEGG:mmu:16367 Irs1
Monarch:16367 Irs1
NCBI Gene:16367 Irs1
UCSC:P35569 Irs1
Reference Transcript
RefSeq:NM_010570.4 Irs1
Participates
as a component of
Active ALK:pY-IRS1 [plasma membrane] (Mus musculus)
Active LTK:p-Y IRS1 [plasma membrane] (Mus musculus)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Other forms of this molecule
p-Irs1 [cytosol]
phospho-Irs1 [plasma membrane]
Irs1 [plasma membrane]
Phospho-IRS1 (by NTRK1) [cytosol]
Irs1 [cytosol]
Irs1 [cytosol]
phospho-Irs1 [plasma membrane]
Inferred From
p-Y-IRS1 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_034700.2
PRO
P35569
GlyGen
P35569
MGI
99454
PDB
1AYB
,
5AXI
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P26450 Pik3r1
5
p-Y-Pik3r1 [cytosol]
(R-MMU-9680631)
Pik3r1 [cytosol]
(R-MMU-3080572)
Pi3k-p85 alpha [cytosol]
(R-MMU-1295777)
Pik3r1 [cytosol]
(R-MMU-74789)
Pik3r1 [plasma membrane]
(R-MMU-198365)
0.702
3
UniProt:P09405
1
Ncl [nucleoplasm]
(R-MMU-6791213)
0.581
3
UniProt:Q1XH17 Trim72
1
Trim72 [cytoplasmic vesicle membrane]
(R-MMU-5333009)
0.576
4
UniProt:Q9CQV8 Ywhab
1
14-3-3 beta/alpha [cytosol]
(R-MMU-1445100)
0.527
2
UniProt:Q13625-2 TP53BP2
0.524
2
UniProt:P67778
2
Phb1 [mitochondrial inner membrane]
(R-MMU-8953720)
Phb1 [cytosol]
(R-MMU-5672944)
0.462
2
UniProt:Q76MZ3 Ppp2r1a
2
Ppp2r1a [nucleoplasm]
(R-MMU-165968)
PP2A A subunit [cytosol]
(R-MMU-206067)
0.462
2
UniProt:P10922
1
H1-0 [nucleoplasm]
(R-MMU-206132)
0.462
2
UniProt:Q02248 Ctnnb1
14
Ctnnb1 [nucleoplasm]
(R-MMU-3451168)
Ctnnb1 [cytosol]
(R-MMU-448839)
Ctnnb1 [cytosol]
(R-MMU-202930)
Ctnnb1 [cytosol]
(R-MMU-202950)
Ctnnb1 [nucleoplasm]
(R-MMU-9735212)
Ctnnb1 [plasma membrane]
(R-MMU-9038440)
Ctnnb1 [plasma membrane]
(R-MMU-9761458)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942374)
beta-catenin [cytosol]
(R-MMU-206225)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942369)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942367)
phospho-Ctnnb1 [cytosol]
(R-MMU-8942363)
phospho-Ctnnb1 [cytosol]
(R-MMU-3134933)
phospho-Ctnnb1 [nucleoplasm]
(R-MMU-3134926)
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text