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phospho-Irs2 [cytosol]
Stable Identifier
R-MMU-74774
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
cytosol
Synonyms
p-Y-IRS2, P81122
Locations in the PathwayBrowser
Expand all
Signal Transduction (Mus musculus)
MAPK family signaling cascades (Mus musculus)
MAPK1/MAPK3 signaling (Mus musculus)
RAF/MAP kinase cascade (Mus musculus)
RAS GEFs promote RAS nucleotide exchange (Mus musculus)
RAS GEFs [plasma membrane] (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
Signaling by Erythropoietin (Mus musculus)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2 (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Mus musculus)
PI3K bound to EPOR [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Mus musculus)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
Signaling by Receptor Tyrosine Kinases (Mus musculus)
Signaling by Insulin receptor (Mus musculus)
Insulin receptor signalling cascade (Mus musculus)
IRS activation (Mus musculus)
Dissociation of IRS-P from insulin receptor (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
Phosphorylation of IRS (Mus musculus)
p-Y-IRS:Insulin:p-6Y-Insulin receptor [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
Signal attenuation (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 dissociates (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
GRB2:p-4S-SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
Signaling by NTRKs (Mus musculus)
Signaling by NTRK1 (TRKA) (Mus musculus)
PI3K/AKT activation (Mus musculus)
Active IRS recruits PI3K to the plasma membrane and activates it (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
PI3K produces PIP3 and other phosphatidyl inositides (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2:PI3K(p85:p110) [plasma membrane] (Mus musculus)
Activated TrkA receptor:Phospho-IRS1/2 [plasma membrane] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) (Mus musculus)
IGF1R signaling cascade (Mus musculus)
IRS-related events triggered by IGF1R (Mus musculus)
IRS-mediated signalling (Mus musculus)
PI3K Cascade (Mus musculus)
PI3K-containing complexes phosphorylate PIP2 to PIP3 (Mus musculus)
PI3K-containing complexes [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
SOS-mediated signalling (Mus musculus)
GRB2-1:SOS1 binds p-IRS1,p-IRS2 (Mus musculus)
GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 bind PI3K (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2:PI3K [cytosol] (Mus musculus)
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
phospho-Irs2 [cytosol] (Mus musculus)
External Reference Information
External Reference
UniProt:P81122 Irs2
Gene Names
Irs2
Chain
chain:1-1321
Reference Genes
BioGPS Gene:384783 Irs2
KEGG:mmu:384783 Irs2
Monarch:384783 Irs2
NCBI Gene:384783 Irs2
UCSC:P81122 Irs2
Reference Transcript
RefSeq:NM_001081212.2 Irs2
Other Identifiers
10576971
1443969_at
17507374
384783
4585546
4739480
4798891
5043042
5411914
5531065
92205_at
A_66_P102260
GO:0002053
GO:0002903
GO:0005068
GO:0005158
GO:0005515
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0007420
GO:0008283
GO:0008284
GO:0008286
GO:0009749
GO:0010631
GO:0010634
GO:0010748
GO:0010907
GO:0016477
GO:0019901
GO:0019903
GO:0019904
GO:0030674
GO:0030879
GO:0030890
GO:0032000
GO:0032024
GO:0032869
GO:0033673
GO:0035591
GO:0043548
GO:0044342
GO:0045725
GO:0046326
GO:0048009
GO:0048856
GO:0048870
GO:0051897
GO:0060090
GO:0071333
GO:0071889
GO:0098772
GO:0141038
GO:1901653
GO:1904692
ILMN_3144164
Participates
as a component of
p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2 [plasma membrane] (Mus musculus)
as a member of
p-Y-IRS1,p-Y-IRS2 [cytosol] (Mus musculus)
Other forms of this molecule
p-Irs2 [cytosol]
Irs2 [plasma membrane]
Phospho-IRS2 (by NTRK1) [cytosol]
Irs2 [cytosol]
Irs2 [cytosol]
phospho-Irs2 [plasma membrane]
Inferred From
p-Y-IRS2 [cytosol]
(Homo sapiens)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001074681.1
ENSEMBL
ENSMUSP00000038514
,
ENSMUST00000040514
,
ENSMUSG00000038894
PRO
P81122
GlyGen
P81122
MGI
109334
PDB
3BU6
,
3BU3
,
3BU5
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P06213-1 INSR
0.655
8
UniProt:Q8CGK3
1
Lonp1 [mitochondrial matrix]
(R-MMU-9838000)
0.508
2
UniProt:P09405
1
Ncl [nucleoplasm]
(R-MMU-6791213)
0.508
2
UniProt:Q8BHZ4 ZN592
0.508
2
UniProt:Q13625-2 TP53BP2
0.482
2
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