Reactome | Casp8 [cytosol]

Casp8 [cytosol]

Stable Identifier

R-MMU-76158

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CASP8(385-479), O89110

Locations in the PathwayBrowser

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Immune System (Mus musculus)

- Cytokine Signaling in Immune system (Mus musculus)
  - Signaling by Interleukins (Mus musculus)
    - Interleukin-1 family signaling (Mus musculus)
      - Interleukin-1 signaling (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
- Innate Immune System (Mus musculus)
  - C-type lectin receptors (CLRs) (Mus musculus)
    - CLEC7A (Dectin-1) signaling (Mus musculus)
      - CLEC7A/inflammasome pathway (Mus musculus)
        
        ASC binds Caspase-8 complex (Mus musculus)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Mus musculus)
        
        MALT1:active caspase-8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        MALT1:active caspase-8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        Caspase-8 binds MALT (Mus musculus)
        
        MALT1:active caspase-8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        Caspase-8 cleaves IL1B precursor (Mus musculus)
        
        MALT1 oligomers:active caspase-8:ASC [cytosol] (Mus musculus)
        
        MALT1:active caspase-8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 10 (TLR10) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
    - Toll Like Receptor 2 (TLR2) Cascade (Mus musculus)
      - Toll Like Receptor TLR1:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
      - Toll Like Receptor TLR6:TLR2 Cascade (Mus musculus)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
    - Toll Like Receptor 3 (TLR3) Cascade (Mus musculus)
      - TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        TRIF-mediated programmed cell death (Mus musculus)
        
        Caspase-8 processing within TLR4 complex (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
    - Toll Like Receptor 5 (TLR5) Cascade (Mus musculus)
      - MyD88 cascade initiated on plasma membrane (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
    - Toll Like Receptor 9 (TLR9) Cascade (Mus musculus)
      - MyD88 dependent cascade initiated on endosome (Mus musculus)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Mus musculus)
        
        TAK1-dependent IKK and NF-kappa-B activation (Mus musculus)
        
        Regulation of NF-kappa B signaling (Mus musculus)
        
        CASP8 cleaves N4BP1 at D424, D490 (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        N4BP1 binds IKBKG (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O89110

Gene Names

Casp8

Reference Genes

BioGPS Gene:12370 Casp8

ENSEMBL:ENSMUSG00000026029

KEGG:mmu:12370 Casp8

Monarch:12370 Casp8

NCBI Gene:12370 Casp8

UCSC:O89110 Casp8

Reference Transcript

Other Identifiers

102328_at

10346564

12370

1424552_at

17213213

4414187

4466287

4605085

4746757

4857306

5020777

5033743

5086615

5215711

5464876

5565320

5566874

5567361

A_51_P247799

GE41643

GO:0001525

GO:0001817

GO:0001841

GO:0003824

GO:0004175

GO:0004197

GO:0005123

GO:0005164

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006508

GO:0006915

GO:0007507

GO:0008233

GO:0008234

GO:0008625

GO:0008656

GO:0012501

GO:0016485

GO:0016787

GO:0030027

GO:0030154

GO:0030225

GO:0030335

GO:0030690

GO:0031264

GO:0031265

GO:0031625

GO:0032731

GO:0032991

GO:0034612

GO:0035877

GO:0036462

GO:0042802

GO:0042981

GO:0043065

GO:0043123

GO:0043124

GO:0043226

GO:0043525

GO:0044297

GO:0044877

GO:0045088

GO:0045471

GO:0045651

GO:0045862

GO:0048738

GO:0048856

GO:0051603

GO:0051604

GO:0060546

GO:0070243

GO:0070266

GO:0070269

GO:0071260

GO:0097110

GO:0097153

GO:0097190

GO:0097191

GO:0097194

GO:0097199

GO:0097264

GO:0097284

GO:0097342

GO:0098772

GO:0140096

GO:1900119

GO:2001233

GO:2001238

ILMN_1243876

ILMN_2457704

ILMN_3097868

Msa.28381.0_s_at

mMC023356

Participates

as a component of

Caspase-8 dimer [cytosol] (Mus musculus)

Other forms of this molecule

Casp8 [cytosol]

Casp8 [mitochondrial outer membrane]

Casp8 [cytosol]

Inferred From

CASP8(385-479) [cytosol] (Homo sapiens)

Cross References

ENSEMBL

ENSMUST00000027189, ENSMUSP00000027189, ENSMUSG00000026029, ENSMUST00000165549, ENSMUSP00000127375

IntEnz

3.4.22.61

PRO

O89110

GlyGen

O89110

MGI

1261423

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q61160	1	Fadd [cytosol] (R-MMU-54639)	0.813	6
UniProt:P25446	1	Fas [plasma membrane] (R-MMU-66248)	0.669	3
UniProt:Q9D8Y7	1	Tnfaip8l2 [cytosol] (R-MMU-8874472)	0.524	2
UniProt:P01375 TNF	5	TNF(1-233) [plasma membrane] (R-HSA-66220) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375)	0.499	2

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