Reactome | Casp8 [cytosol]

Casp8 [cytosol]

Stable Identifier

R-MMU-76158

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

CASP8(385-479), O89110

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Innate Immune System (Mus musculus)
  - C-type lectin receptors (CLRs) (Mus musculus)
    - CLEC7A (Dectin-1) signaling (Mus musculus)
      - CLEC7A/inflammasome pathway (Mus musculus)
        
        Caspase-8 binds MALT (Mus musculus)
        
        MALT1:active caspase-8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)
  - Toll-like Receptor Cascades (Mus musculus)
    - Toll Like Receptor 4 (TLR4) Cascade (Mus musculus)
      - MyD88-independent TLR4 cascade (Mus musculus)
        
        TRIF(TICAM1)-mediated TLR4 signaling (Mus musculus)
        
        TRIF-mediated programmed cell death (Mus musculus)
        
        Caspase-8 processing within TLR4 complex (Mus musculus)
        
        active caspase-8 [cytosol] (Mus musculus)
        
        Caspase-8 dimer [cytosol] (Mus musculus)
        
        Casp8 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:O89110

Gene Names

Casp8

Reference Genes

BioGPS Gene:12370 Casp8

ENSEMBL:ENSMUSG00000026029

ENSEMBL:ENSMUSG00000026029 Casp8

KEGG Gene (Mus musculus):12370 Casp8

Monarch:12370 Casp8

NCBI Gene:12370 Casp8

UCSC:O89110 Casp8

Reference Transcript

Other Identifiers

102328_at

10346564

12370

1424552_at

17213213

4414187

4466287

4605085

4746757

4857306

5020777

5033743

5086615

5215711

5464876

5566874

5567361

A_51_P247799

GE41643

GO:0003674

GO:0004197

GO:0005515

GO:0006508

GO:0008150

GO:0008219

GO:0008233

GO:0008234

GO:0042981

ILMN_1243876

ILMN_3097868

Msa.28381.0_s_at

mMC023356

Participates

as a component of

Caspase-8 dimer [cytosol] (Mus musculus)

Other forms of this molecule

Casp8 [mitochondrial outer membrane]

Casp8 [cytosol]

Inferred From

CASP8(385-479) [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_033942.1, NP_001073595.1

IntEnz

3.4.22.61

Ensembl

ENSMUSP00000127375, ENSMUST00000165549, ENSMUSP00000027189, ENSMUST00000027189, ENSMUSG00000026029

PRO

O89110

MGI

1261423

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q61160	1	Fadd [cytosol] (R-MMU-54639)	0.813	6
UniProt:P25446	1	Fas [plasma membrane] (R-MMU-66248)	0.669	3
UniProt:Q9D8Y7	1	Tnfaip8l2 [cytosol] (R-MMU-8874472)	0.524	2
UniProt:P01375 TNF	5	TNF(1-34) [plasma membrane] (R-HSA-8863367) TNF(52-76) [extracellular region] (R-HSA-8863375) TNF(1-76) [plasma membrane] (R-HSA-8863120) TNF(77-233) [extracellular region] (R-HSA-976821) TNF(1-233) [plasma membrane] (R-HSA-66220)	0.499	2